SUMO4 and LDHB

Number of citations of the paper that reports this interaction (PMID 16236267)
15

Data Source:
HPRD (in vivo)

		SUMO4	LDHB
Gene Name		small ubiquitin-like modifier 4	lactate dehydrogenase B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Cytoplasm Mitochondrion Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function		L-lactate Dehydrogenase Activity Protein Binding Kinase Binding Identical Protein Binding NAD Binding
	Biological Process	Protein Sumoylation	Lactate Metabolic Process Pyruvate Metabolic Process NAD Metabolic Process Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			Pyruvate metabolism Abnormal metabolism in phenylketonuria Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH Nicotinamide-Adenine-Dinucleotide 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid Oxamic Acid
Diseases
GWAS
Protein-Protein Interactions		75 interactors: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GNB2L1 GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1	7 interactors: CKS1B CKS2 LDHA PEX5 POT1 SUMO4 TERF1
Entrez ID		387082	3945
HPRD ID		10584	01026
Ensembl ID		ENSG00000177688	ENSG00000111716
Uniprot IDs		Q6EEV6	P07195 Q5U077
PDB IDs			1I0Z 1T2F
Enriched GO Terms of Interacting Partners?		Protein Folding Regulation Of Cell Death Regulation Of Apoptotic Process Cellular Metabolic Process Response To Unfolded Protein Response To Stress Negative Regulation Of Cell Death 'de Novo' Protein Folding Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Toxin Transport Response To Organic Substance Nitrogen Compound Metabolic Process 'de Novo' Posttranslational Protein Folding Metabolic Process Cellular Response To Stress Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Endoplasmic Reticulum Stress Generation Of Precursor Metabolites And Energy Regulation Of Cellular Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Process Response To Reactive Oxygen Species Small Molecule Metabolic Process Organic Acid Metabolic Process Hydrogen Peroxide Catabolic Process Regulation Of Protein Metabolic Process Carboxylic Acid Metabolic Process Protein Refolding Endoplasmic Reticulum Unfolded Protein Response Ribonucleoside Monophosphate Biosynthetic Process Carbohydrate Biosynthetic Process Cellular Response To Organic Substance MRNA Metabolic Process Cellular Response To Unfolded Protein Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Nucleoside Monophosphate Biosynthetic Process Gluconeogenesis Monocarboxylic Acid Metabolic Process ER-nucleus Signaling Pathway Catabolic Process Ribose Phosphate Biosynthetic Process Apoptotic Process Biosynthetic Process Cellular Response To Topologically Incorrect Protein	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Maintenance Cell Division Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Homotetramerization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Replication Protein Import Into Peroxisome Matrix, Translocation Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase Protein Import Into Peroxisome Matrix, Docking Telomere Maintenance Via Telomere Shortening Regulation Of Chromosome Organization Telomere Capping Negative Regulation Of Protein Homooligomerization Positive Regulation Of Helicase Activity Regulation Of Cell Cycle Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Protein Import Into Peroxisome Membrane Protein To Membrane Docking Mitotic Cell Cycle Phase Transition Peroxisomal Membrane Transport Cell Cycle Phase Transition Cell Cycle Process Replicative Cell Aging Negative Regulation Of Protein Oligomerization Regulation Of Catalytic Activity DNA Replication Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Negative Regulation Of Transferase Activity Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Polymerization
Tagcloud ?		accumulating behcet ccr1 ccr3 ccr6 cd40 ctla4 elucidating fcrl3 han helpful hopefully il17 il23r immunoregulatory irf5 l2 mcp multisystemic mystery opn predisposition profound ptpn22 regimes stat4 tgfbr3 tgrbr3 ubac2	basal bimodal cancers chemotherapy datasets dehydrogenase dependence glycolytic heterogeneous highest lactate linking metabolic microarray molecularly neoadjuvant pam50 pathologic phenotypes posttreatment predict predicted predictive relapse robust scoring subtypes subtyping triple
Tagcloud (Difference) ?		accumulating behcet ccr1 ccr3 ccr6 cd40 ctla4 elucidating fcrl3 han helpful hopefully il17 il23r immunoregulatory irf5 l2 mcp multisystemic mystery opn predisposition profound ptpn22 regimes stat4 tgfbr3 tgrbr3 ubac2	basal bimodal cancers chemotherapy datasets dehydrogenase dependence glycolytic heterogeneous highest lactate linking metabolic microarray molecularly neoadjuvant pam50 pathologic phenotypes posttreatment predict predicted predictive relapse robust scoring subtypes subtyping triple
Tagcloud (Intersection) ?