PFDN1 and IFT140

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PFDN1	IFT140
Gene Name		prefoldin subunit 1	intraflagellar transport 140
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Prefoldin Complex	Centrosome Axoneme Intraciliary Transport Particle A Photoreceptor Connecting Cilium Ciliary Basal Body Primary Cilium Ciliary Tip
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Unfolded Protein Binding	Molecular_function
	Biological Process	Regulation Of Transcription, DNA-templated Protein Folding Cell Cycle Telencephalon Development Cerebellum Development Actin Cytoskeleton Organization B Cell Activation Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding	Organelle Organization Intraciliary Retrograde Transport Cilium Assembly Skeletal System Morphogenesis Retina Development In Camera-type Eye Protein Localization To Cilium Renal System Development Regulation Of Cilium Assembly
Pathways		Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding	Organelle biogenesis and maintenance Hedgehog 'off' state Signaling by Hedgehog Assembly of the primary cilium Intraflagellar transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		54 interactors: ACTA1 ACTB ALB ASNA1 BRK1 CCDC85A CHGA DCTN1 DEFA1 DGCR14 EDRF1 EIF3C EIF4A2 EOMES EXT2 EZH2 FAM20C GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 KIAA1377 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 TUBA1A YEATS4 ZNF235	4 interactors: CELSR3 NEK2 PFDN1 RANBP2
Entrez ID		5201	9742
HPRD ID		05357	11093
Ensembl ID		ENSG00000113068	ENSG00000187535
Uniprot IDs		O60925	Q96RY7
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Cellular Localization Cellular Macromolecule Biosynthetic Process Cellular Component Assembly Macromolecule Biosynthetic Process Gene Expression Membrane Organization RNA Biosynthetic Process Cellular Protein Localization Establishment Of Protein Localization To Membrane Protein Localization Developmental Process Cerebral Cortex Regionalization Mitotic Cell Cycle Biosynthetic Process Cellular Process Cytoskeleton-dependent Intracellular Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cellular Metabolic Process Establishment Of Localization In Cell Anatomical Structure Development RNA Metabolic Process Organelle Localization 'de Novo' Posttranslational Protein Folding Intracellular Transport Cell Cycle Process 'de Novo' Protein Folding Regulation Of Metabolic Process Telencephalon Regionalization Regulation Of Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Protein Localization To Organelle Positive Regulation Of Cellular Metabolic Process Protein Localization To Membrane Vesicle Localization Regulation Of Cilium Assembly Multicellular Organismal Development Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Phase Transition Anatomical Structure Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Killing Of Cells Of Other Organism Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Anatomical Structure Formation Involved In Morphogenesis	Negative Regulation Of Centriole-centriole Cohesion Organelle Organization Regulation Of Centriole-centriole Cohesion Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Cell Cycle Regulation Of Mitotic Centrosome Separation Protein Folding Negative Regulation Of Glucokinase Activity Organelle Assembly Centrosome Separation Mitotic Spindle Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore Axonal Fasciculation Protein Sumoylation
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