PER1 and PER2

Number of citations of the paper that reports this interaction (PMID 10848614)
63

Data Source:
HPRD (in vivo)

		PER1	PER2
Gene Name		period circadian clock 1	period circadian clock 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity Signal Transducer Activity Transcription Factor Binding Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding E-box Binding	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity Core Promoter Binding Transcription Corepressor Binding Transcription Coactivator Activity Signal Transducer Activity Protein Binding Kinase Binding Nuclear Hormone Receptor Binding Pre-mRNA Binding Histone Deacetylase Binding Ubiquitin Binding RNA Polymerase Binding Histone Methyltransferase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sodium Ion Transport Transcription, DNA-templated Signal Transduction Circadian Rhythm Entrainment Of Circadian Clock Posttranscriptional Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Entrainment Of Circadian Clock By Photoperiod Histone H3 Acetylation Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Response To CAMP Histone H3 Deacetylation Circadian Regulation Of Translation Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of P38MAPK Cascade Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Ischemia Glycogen Biosynthetic Process Gluconeogenesis Transcription, DNA-templated Fatty Acid Metabolic Process Signal Transduction Circadian Rhythm Regulation Of Vasoconstriction Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis Regulation Of Insulin Secretion White Fat Cell Differentiation Regulation Of Cell Cycle Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Negative Regulation Of DNA-templated Transcription, Termination Negative Regulation Of Fat Cell Proliferation Histone H3 Deacetylation Circadian Regulation Of Translation Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CCDC57 CRY1 CRY2 CSNK1D CSNK1E CSNK1G2 FAM65B GPRASP1 HIF1A PER2 PER3 RBPMS TIMELESS	9 interactors: CRY1 CRY2 CSNK1D CSNK1E PER1 PER3 TIMELESS TP53 TPT1
Entrez ID		5187	8864
HPRD ID		03774	04575
Ensembl ID		ENSG00000179094	ENSG00000132326
Uniprot IDs		O15534	O15055
PDB IDs		1UL6
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Rhythm Circadian Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Circadian Rhythm Blue Light Signaling Pathway Response To Blue Light Regulation Of Signaling Lactate Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Nitrogen Compound Metabolic Process Protein-chromophore Linkage Negative Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-serine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Shape Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Photoperiodism Entrainment Of Circadian Clock Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Glucose Homeostasis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Hormone Secretion Cell Cycle Phase Transition Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Wnt Signaling Pathway RNA Metabolic Process Gluconeogenesis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Hexose Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription, Termination	Regulation Of Circadian Rhythm Circadian Rhythm Rhythmic Process Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Blue Light Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Blue Light Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Light Stimulus Cellular Response To Light Stimulus Cellular Response To DNA Damage Stimulus Regulation Of Signal Transduction Protein-chromophore Linkage Response To Radiation Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Regulation Of Signaling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Circadian Rhythm Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA Repair Transcription, DNA-templated Nitrogen Compound Metabolic Process RNA Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Process Cell Cycle Phase Transition Mitotic Cell Cycle Cellular Response To Stress Cellular Response To Stimulus Response To External Stimulus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		acutely afternoon bmal1 boivin bright cermakian circadian clock clocks cortef cuesta desynchronization entrain entrained glucocorticoids innovative jet lag night pbmcs per2 reset rhythms shifted synchronize synchronizers synchronizing travelers underlines	aperiodic arnt brighton brosens chan circadian clock conceptus congruently cryptochrome decidual decidualizing disorganized grossly hescs kaput lacey lucas midluteal miscarriages moore muter oscillations predicated preponderance quenby silences synchronizes uncoupling
Tagcloud (Difference) ?		acutely afternoon bmal1 boivin bright cermakian clocks cortef cuesta desynchronization entrain entrained glucocorticoids innovative jet lag night pbmcs reset rhythms shifted synchronize synchronizers synchronizing travelers underlines	aperiodic arnt brighton brosens chan conceptus congruently cryptochrome decidual decidualizing disorganized grossly hescs kaput lacey lucas midluteal miscarriages moore muter oscillations predicated preponderance quenby silences synchronizes uncoupling
Tagcloud (Intersection) ?		circadian clock per2