PDE4D and PDE4DIP

Number of citations of the paper that reports this interaction (PMID 11134006)
49

Data Source:
HPRD (two hybrid, in vivo)

		PDE4D	PDE4DIP
Gene Name		phosphodiesterase 4D, cAMP-specific	phosphodiesterase 4D interacting protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Centrosome Cytosol Voltage-gated Calcium Channel Complex Membrane Apical Plasma Membrane Myofibril Calcium Channel Complex	Nucleus Cytoplasm Golgi Apparatus Centrosome Myofibril
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Drug Binding SH3 Domain Binding Enzyme Binding CAMP Binding Ubiquitin Protein Ligase Binding Beta-2 Adrenergic Receptor Binding Ion Channel Binding Metal Ion Binding ATPase Binding Scaffold Protein Binding	Protein Binding Enzyme Binding
	Biological Process	Regulation Of Heart Rate CAMP Catabolic Process Smooth Muscle Contraction Aging Memory Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Receptor Activity Regulation Of Protein Kinase A Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Smooth Muscle Cell Migration CAMP-mediated Signaling Lung Development Neutrophil Chemotaxis Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-5 Production Negative Regulation Of Peptidyl-serine Phosphorylation Multicellular Organism Growth Cellular Protein Complex Assembly Negative Regulation Of Heart Contraction Positive Regulation Of Smooth Muscle Cell Proliferation T Cell Receptor Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Establishment Of Endothelial Barrier Cellular Response To Lipopolysaccharide Cellular Response To CAMP Cellular Response To Epinephrine Stimulus Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Relaxation Of Cardiac Muscle	Cellular Protein Complex Assembly
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Opioid Signalling DARPP-32 events
Drugs		Adenosine monophosphate Dyphylline Ketotifen Iloprost Roflumilast Piclamilast 4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol 6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester (S)-Rolipram Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid (R)-Rolipram 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Ibudilast (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-ISOBUTYL-1-METHYLXANTHINE 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) ( 23648065) Asthma ( 19426955) Breast cancer ( 23535729) Esophageal cancer ( 21642993) Immune response to smallpox vaccine (IL-6) ( 22610502) Neuroticism ( 17667963) Obesity-related traits ( 23251661) Response to antipsychotic treatment ( 23241943) Sleepiness ( 17903308)	Capecitabine sensitivity ( 22864933)
Protein-Protein Interactions		25 interactors: ABL1 AKAP6 APP ARRB1 ARRB2 COIL CSNK1A1 FYN GNB2L1 GOLGA8EP GOLGA8F GRB2 GSK3B LYN MAGEA6 MAPK1 MDM2 PAFAH1B1 PDE4DIP PIAS4 PIK3CA PRKACA SPTBN1 SRC TRAF1	64 interactors: ADH1B AEN ANKRD11 ARNT2 BYSL C14orf105 C19orf66 C1orf109 CCDC146 CDC5L CDKN1A CHCHD3 FAM161A FAM74A4 FCHSD2 FES FHL1 GADD45G GFI1B GOLGA8EP GOLGA8F HAUS1 IMMT ITSN2 KDM1A KLC3 KLC4 KRAS KRT18 KRT31 LAMTOR3 LENG1 LMO4 MAPRE1 MIF4GD MTUS2 NAA10 NEFL NEK2 OSGEP PDE4D PFDN1 PIAS4 PPP1R18 PRNP PRPF31 RTP5 SCNM1 SDCBP SH2D4A SMN1 SNCA TFIP11 TK1 TNIK TRAF4 UTP14C VAC14 ZBTB38 ZFYVE21 ZNF408 ZNF512B ZNF581 ZSCAN26
Entrez ID		5144	9659
HPRD ID		02530	10482
Ensembl ID		ENSG00000113448	ENSG00000178104
Uniprot IDs		Q08499	F8WAP3 Q5VU43
PDB IDs		1E9K 1MKD 1OYN 1PTW 1Q9M 1TB7 1TBB 1XOM 1XON 1XOQ 1XOR 1Y2B 1Y2C 1Y2D 1Y2E 1Y2K 1ZKN 2FM0 2FM5 2PW3 2QYN 3G4G 3G4I 3G4K 3G4L 3G58 3IAD 3IAK 3K4S 3SL3 3SL4 3SL5 3SL6 3SL8 3V9B
Enriched GO Terms of Interacting Partners?		Platelet Activation Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Hemostasis Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Body Fluid Levels Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Wound Healing Fibroblast Growth Factor Receptor Signaling Pathway Chemotaxis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Endocytosis Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cellular Component Organization Cell Activation Response To Fibroblast Growth Factor Positive Regulation Of Protein Metabolic Process Response To Wounding Locomotion Regulation Of Cellular Ketone Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorylation Axonogenesis Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Axon Development Negative Regulation Of Signal Transduction Axon Guidance Innate Immune Response Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Apoptotic Process Phagocytosis Movement Of Cell Or Subcellular Component Regulation Of MAPK Cascade Negative Regulation Of Signaling Negative Regulation Of Protein Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neuron Projection Morphogenesis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Cell Death	Developmental Process Response To Copper Ion RNA Metabolic Process Anatomical Structure Development Nucleobase-containing Compound Metabolic Process Regulation Of Microtubule Polymerization Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Copper Ion Response To Mineralocorticoid Cellular Nitrogen Compound Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cell Death Regulation Of Phosphorylation Response To Glucocorticoid Regulation Of JNK Cascade Activation Of MAPKK Activity Positive Regulation Of Protein Kinase Activity Nitrogen Compound Metabolic Process Response To Corticosteroid Regulation Of Metabolic Process Regulation Of Microtubule-based Process Negative Regulation Of Microtubule Polymerization Negative Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Microtubule Polymerization Or Depolymerization Cellular Response To Epinephrine Stimulus Regulation Of Cellular Component Organization System Development Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Response To Epinephrine RNA Splicing Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Death Positive Regulation Of Transferase Activity Regulation Of Histone H3-K4 Methylation Regulation Of Kinase Activity Embryo Development Ending In Birth Or Egg Hatching MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde11a pde2a pde3a pde3b pde4a phosphodiesterase select splicing xrn2
Tagcloud (Difference) ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde11a pde2a pde3a pde3b pde4a phosphodiesterase select splicing xrn2
Tagcloud (Intersection) ?