PDE4D and COIL

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PDE4D	COIL
Gene Name		phosphodiesterase 4D, cAMP-specific	coilin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Centrosome Cytosol Voltage-gated Calcium Channel Complex Membrane Apical Plasma Membrane Myofibril Calcium Channel Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Drug Binding SH3 Domain Binding Enzyme Binding CAMP Binding Ubiquitin Protein Ligase Binding Beta-2 Adrenergic Receptor Binding Ion Channel Binding Metal Ion Binding ATPase Binding Scaffold Protein Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	Regulation Of Heart Rate CAMP Catabolic Process Smooth Muscle Contraction Aging Memory Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Receptor Activity Regulation Of Protein Kinase A Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Smooth Muscle Cell Migration CAMP-mediated Signaling Lung Development Neutrophil Chemotaxis Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-5 Production Negative Regulation Of Peptidyl-serine Phosphorylation Multicellular Organism Growth Cellular Protein Complex Assembly Negative Regulation Of Heart Contraction Positive Regulation Of Smooth Muscle Cell Proliferation T Cell Receptor Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Establishment Of Endothelial Barrier Cellular Response To Lipopolysaccharide Cellular Response To CAMP Cellular Response To Epinephrine Stimulus Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Relaxation Of Cardiac Muscle
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Opioid Signalling DARPP-32 events
Drugs		Adenosine monophosphate Dyphylline Ketotifen Iloprost Roflumilast Piclamilast 4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol 6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester (S)-Rolipram Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid (R)-Rolipram 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Ibudilast (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-ISOBUTYL-1-METHYLXANTHINE 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) ( 23648065) Asthma ( 19426955) Breast cancer ( 23535729) Esophageal cancer ( 21642993) Immune response to smallpox vaccine (IL-6) ( 22610502) Neuroticism ( 17667963) Obesity-related traits ( 23251661) Response to antipsychotic treatment ( 23241943) Sleepiness ( 17903308)	Height ( 18391951)
Protein-Protein Interactions		25 interactors: ABL1 AKAP6 APP ARRB1 ARRB2 COIL CSNK1A1 FYN GNB2L1 GOLGA8EP GOLGA8F GRB2 GSK3B LYN MAGEA6 MAPK1 MDM2 PAFAH1B1 PDE4DIP PIAS4 PIK3CA PRKACA SPTBN1 SRC TRAF1	70 interactors: ACTN1 ACTN2 ACTN4 APP ARMCX1 ATXN1 ATXN1L BYSL C1QBP CCDC136 CCDC159 CCNE1 CDC23 CDK2 CEP70 CEP76 CSNK2B CYB5R2 DHX16 DNAJA3 DRG1 FGF12 FHL5 FXR2 GCC1 KALRN KAZN KLC2 KLC4 KLHL42 KLHL8 KPNA3 LNX1 MAD1L1 MFAP1 MYO5B NIF3L1 NOLC1 NUDT18 PDE4D PDLIM5 PIAS4 PICK1 PLEKHG4 POLR2L PREPL PRMT1 PRMT8 PSMA1 PSME3 PTS SART3 SCYL1 SMN1 SNRPB SNRPF SNX6 TAF9 TCAF1 TCEB3B TFCP2 TGS1 TSPYL2 WDR34 WDYHV1 XRCC5 XRCC6 ZBTB25 ZCCHC10 ZNF277
Entrez ID		5144	8161
HPRD ID		02530	02605
Ensembl ID		ENSG00000113448	ENSG00000121058
Uniprot IDs		Q08499	P38432
PDB IDs		1E9K 1MKD 1OYN 1PTW 1Q9M 1TB7 1TBB 1XOM 1XON 1XOQ 1XOR 1Y2B 1Y2C 1Y2D 1Y2E 1Y2K 1ZKN 2FM0 2FM5 2PW3 2QYN 3G4G 3G4I 3G4K 3G4L 3G58 3IAD 3IAK 3K4S 3SL3 3SL4 3SL5 3SL6 3SL8 3V9B
Enriched GO Terms of Interacting Partners?		Platelet Activation Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Hemostasis Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Body Fluid Levels Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Wound Healing Fibroblast Growth Factor Receptor Signaling Pathway Chemotaxis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Endocytosis Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cellular Component Organization Cell Activation Response To Fibroblast Growth Factor Positive Regulation Of Protein Metabolic Process Response To Wounding Locomotion Regulation Of Cellular Ketone Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorylation Axonogenesis Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Axon Development Negative Regulation Of Signal Transduction Axon Guidance Innate Immune Response Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Apoptotic Process Phagocytosis Movement Of Cell Or Subcellular Component Regulation Of MAPK Cascade Negative Regulation Of Signaling Negative Regulation Of Protein Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neuron Projection Morphogenesis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Cell Death	Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Spliceosomal SnRNP Assembly Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process MRNA Processing Ribonucleoprotein Complex Biogenesis RNA Processing Regulation Of Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Mitotic Cell Cycle RNA Splicing Gene Expression Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Ribonucleoprotein Complex Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Hyperosmotic Salinity Response Protein Localization To Tight Junction Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of RNA Metabolic Process MRNA Metabolic Process Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of Protein Metabolic Process Platelet Degranulation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Gene Expression Cellular Response To X-ray Regulation Of Ubiquitin-protein Transferase Activity Viral Process Cellular Component Assembly
Tagcloud ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde11a pde2a pde3a pde3b pde4a phosphodiesterase select splicing xrn2	augment augments bait cbp coactivator coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast
Tagcloud (Difference) ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde11a pde2a pde3a pde3b pde4a phosphodiesterase select splicing xrn2	augment augments bait cbp coactivator coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast
Tagcloud (Intersection) ?