PC and GOT1

Number of citations of the paper that reports this interaction (PMID 8349677)
3

Data Source:
BioGRID (pull down)

		PC	GOT1
Gene Name		pyruvate carboxylase	glutamic-oxaloacetic transaminase 1, soluble
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol	Nucleus Cytoplasm Lysosome Cytosol Axon Terminus Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Biotin Carboxylase Activity Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Metal Ion Binding	L-aspartate:2-oxoglutarate Aminotransferase Activity Phosphatidylserine Decarboxylase Activity Pyridoxal Phosphate Binding Carboxylic Acid Binding L-cysteine:2-oxoglutarate Aminotransferase Activity L-phenylalanine:2-oxoglutarate Aminotransferase Activity
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Pyruvate Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process Lipid Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Pathogenesis Small Molecule Metabolic Process	Sulfur Amino Acid Metabolic Process Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Glycerol Biosynthetic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Polyamine Metabolic Process Cellular Amino Acid Biosynthetic Process Pathogenesis L-methionine Biosynthetic Process From Methylthioadenosine Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Cellular Response To Insulin Stimulus Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Response To Glucocorticoid Fatty Acid Homeostasis
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Gluconeogenesis Glucose metabolism Defective AMN causes hereditary megaloblastic anemia 1 Myoclonic epilepsy of Lafora Glycogen storage diseases Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Metabolism of carbohydrates Biotin transport and metabolism Defects in vitamin and cofactor metabolism	Gluconeogenesis Glucose metabolism Metabolism of polyamines Myoclonic epilepsy of Lafora Glycogen storage diseases Amino acid synthesis and interconversion (transamination) Sulfur amino acid metabolism Metabolism of carbohydrates Methionine salvage pathway Metabolism of amino acids and derivatives
Drugs		Pyruvic acid Biotin 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL	Pyridoxal Phosphate L-Aspartic Acid L-Glutamic Acid L-Cysteine Maleic Acid
Diseases
GWAS		Bipolar disorder ( 21926972) HIV-1 susceptibility ( 22174851)	Aspartate aminotransferase ( 21900944) Crohn's disease ( 22412388)
Protein-Protein Interactions		3 interactors: GOT1 GOT2 MDH2	4 interactors: ABI3BP EGFR PC TMEM120A
Entrez ID		5091	2805
HPRD ID		02032	00687
Ensembl ID		ENSG00000173599	ENSG00000120053
Uniprot IDs		P11498	B7Z1I2 B7Z7E9 P17174
PDB IDs		3BG3 3BG9	3II0
Enriched GO Terms of Interacting Partners?		Oxaloacetate Metabolic Process Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Gluconeogenesis Hexose Biosynthetic Process Fumarate Metabolic Process Aspartate Catabolic Process Dicarboxylic Acid Metabolic Process Glutamate Catabolic Process Glucose Metabolic Process Aspartate Metabolic Process Carbohydrate Biosynthetic Process Pathogenesis Hexose Metabolic Process Dicarboxylic Acid Catabolic Process Monosaccharide Metabolic Process 2-oxoglutarate Metabolic Process Glutamate Metabolic Process Cellular Amino Acid Catabolic Process Carboxylic Acid Metabolic Process Carbohydrate Metabolic Process Cellular Amino Acid Biosynthetic Process Organic Acid Metabolic Process Carboxylic Acid Catabolic Process Cellular Carbohydrate Metabolic Process Glycerol Biosynthetic Process Alpha-amino Acid Metabolic Process 4-hydroxyproline Catabolic Process L-kynurenine Metabolic Process Small Molecule Metabolic Process L-methionine Biosynthetic Process From Methylthioadenosine Cellular Amino Acid Metabolic Process L-methionine Salvage Kynurenine Metabolic Process Fatty Acid Homeostasis NADH Metabolic Process Malate Metabolic Process Methionine Biosynthetic Process Methionine Metabolic Process 4-hydroxyproline Metabolic Process Cellular Modified Amino Acid Catabolic Process Sulfur Amino Acid Biosynthetic Process Polyamine Metabolic Process Glycerol Metabolic Process Tricarboxylic Acid Cycle Sulfur Amino Acid Metabolic Process Citrate Metabolic Process Anion Homeostasis NAD Metabolic Process	Alkanesulfonate Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Activation Of Phospholipase A2 Activity Positive Regulation Of Phospholipase A2 Activity Response To Cobalamin Response To UV-A Response To Hydroxyisoflavone Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Sulfur Compound Metabolic Process Positive Regulation Of Catenin Import Into Nucleus
Tagcloud ?		47d accordance acetyltransferase ar ara70 bridging caf classic cloning coactivator coactivators coordinate cos deduced differs du ele1 ele1alpha ele1beta glucocorticoid gr hela isoform leucine lncap nonallelic rfg steroid testis tfiib	aqp3 aqp9 aquaporin cancerous cbm comprehensively constraint counter g6pc gk glucogenic gluconeogenesis glutamic glycerol glycolysis hgp imposed initiates oxaloacetic pck2 pentose portray ppp represses shunted statuses supplying transaminase transcriptomic
Tagcloud (Difference) ?		47d accordance acetyltransferase ar ara70 bridging caf classic cloning coactivator coactivators coordinate cos deduced differs du ele1 ele1alpha ele1beta glucocorticoid gr hela isoform leucine lncap nonallelic rfg steroid testis tfiib	aqp3 aqp9 aquaporin cancerous cbm comprehensively constraint counter g6pc gk glucogenic gluconeogenesis glutamic glycerol glycolysis hgp imposed initiates oxaloacetic pck2 pentose portray ppp represses shunted statuses supplying transaminase transcriptomic
Tagcloud (Intersection) ?