GOT1 and ABI3BP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GOT1	ABI3BP
Gene Name		glutamic-oxaloacetic transaminase 1, soluble	ABI family, member 3 (NESH) binding protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Axon Terminus Extracellular Vesicular Exosome	Interstitial Matrix Extracellular Space Extracellular Matrix
	Molecular Function	L-aspartate:2-oxoglutarate Aminotransferase Activity Phosphatidylserine Decarboxylase Activity Pyridoxal Phosphate Binding Carboxylic Acid Binding L-cysteine:2-oxoglutarate Aminotransferase Activity L-phenylalanine:2-oxoglutarate Aminotransferase Activity	Collagen Binding Heparin Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Glycerol Biosynthetic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Polyamine Metabolic Process Cellular Amino Acid Biosynthetic Process Pathogenesis L-methionine Biosynthetic Process From Methylthioadenosine Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Cellular Response To Insulin Stimulus Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Response To Glucocorticoid Fatty Acid Homeostasis	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization
Pathways		Gluconeogenesis Glucose metabolism Metabolism of polyamines Myoclonic epilepsy of Lafora Glycogen storage diseases Amino acid synthesis and interconversion (transamination) Sulfur amino acid metabolism Metabolism of carbohydrates Methionine salvage pathway Metabolism of amino acids and derivatives
Drugs		Pyridoxal Phosphate L-Aspartic Acid L-Glutamic Acid L-Cysteine Maleic Acid
Diseases
GWAS		Aspartate aminotransferase ( 21900944) Crohn's disease ( 22412388)
Protein-Protein Interactions		4 interactors: ABI3BP EGFR PC TMEM120A	6 interactors: ABI3 CBX1 FZD5 GOT1 GRB2 MBNL1
Entrez ID		2805	25890
HPRD ID		00687	09380
Ensembl ID		ENSG00000120053	ENSG00000154175
Uniprot IDs		B7Z1I2 B7Z7E9 P17174	D3YTG3 Q7Z7G0
PDB IDs		3II0
Enriched GO Terms of Interacting Partners?		Alkanesulfonate Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Activation Of Phospholipase A2 Activity Positive Regulation Of Phospholipase A2 Activity Response To Cobalamin Response To UV-A Response To Hydroxyisoflavone Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Sulfur Compound Metabolic Process Positive Regulation Of Catenin Import Into Nucleus	Branching Involved In Labyrinthine Layer Morphogenesis Labyrinthine Layer Morphogenesis Embryonic Placenta Morphogenesis Labyrinthine Layer Development In Utero Embryonic Development Embryonic Placenta Development Embryonic Morphogenesis Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Chorionic Trophoblast Cell Proliferation Spemann Organizer Formation Fumarate Metabolic Process Glycerol Biosynthetic Process Aspartate Catabolic Process Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Placenta Development Cellular Response To Insulin Stimulus Morphogenesis Of A Branching Epithelium Glutamate Catabolic Process Morphogenesis Of A Branching Structure Aspartate Metabolic Process Chorionic Trophoblast Cell Differentiation Embryo Development Chorion Development Response To Insulin L-methionine Biosynthetic Process From Methylthioadenosine Cellular Response To Peptide Hormone Stimulus Regulation Of Tight Junction Assembly Cellular Response To Peptide L-methionine Salvage Post-embryonic Camera-type Eye Development Alternative MRNA Splicing, Via Spliceosome Dicarboxylic Acid Catabolic Process Fatty Acid Homeostasis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Methionine Biosynthetic Process Anterior/posterior Axis Specification, Embryo Methionine Metabolic Process Response To Peptide Hormone Cellular Response To Organonitrogen Compound Sulfur Amino Acid Biosynthetic Process Response To Peptide Embryonic Organ Development Glutamate Metabolic Process Apoptotic Process Involved In Morphogenesis
Tagcloud ?		aqp3 aqp9 aquaporin cancerous cbm comprehensively constraint counter g6pc gk glucogenic gluconeogenesis glutamic glycerol glycolysis hgp imposed initiates oxaloacetic pck2 pentose portray ppp represses shunted statuses supplying transaminase transcriptomic	angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached rims1 scan spanish suffering suggestive t13 unrelated urticaria
Tagcloud (Difference) ?		aqp3 aqp9 aquaporin cancerous cbm comprehensively constraint counter g6pc gk glucogenic gluconeogenesis glutamic glycerol glycolysis hgp imposed initiates oxaloacetic pck2 pentose portray ppp represses shunted statuses supplying transaminase transcriptomic	angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached rims1 scan spanish suffering suggestive t13 unrelated urticaria
Tagcloud (Intersection) ?