GOT1 and TMEM120A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		GOT1	TMEM120A
Gene Name		glutamic-oxaloacetic transaminase 1, soluble	transmembrane protein 120A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Axon Terminus Extracellular Vesicular Exosome	Cellular_component Integral Component Of Membrane
	Molecular Function	L-aspartate:2-oxoglutarate Aminotransferase Activity Phosphatidylserine Decarboxylase Activity Pyridoxal Phosphate Binding Carboxylic Acid Binding L-cysteine:2-oxoglutarate Aminotransferase Activity L-phenylalanine:2-oxoglutarate Aminotransferase Activity	Molecular_function
	Biological Process	Sulfur Amino Acid Metabolic Process Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Glycerol Biosynthetic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Polyamine Metabolic Process Cellular Amino Acid Biosynthetic Process Pathogenesis L-methionine Biosynthetic Process From Methylthioadenosine Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Cellular Response To Insulin Stimulus Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Response To Glucocorticoid Fatty Acid Homeostasis	Biological_process
Pathways		Gluconeogenesis Glucose metabolism Metabolism of polyamines Myoclonic epilepsy of Lafora Glycogen storage diseases Amino acid synthesis and interconversion (transamination) Sulfur amino acid metabolism Metabolism of carbohydrates Methionine salvage pathway Metabolism of amino acids and derivatives
Drugs		Pyridoxal Phosphate L-Aspartic Acid L-Glutamic Acid L-Cysteine Maleic Acid
Diseases
GWAS		Aspartate aminotransferase ( 21900944) Crohn's disease ( 22412388)
Protein-Protein Interactions		4 interactors: ABI3BP EGFR PC TMEM120A	4 interactors: GOT1 PAXIP1 PPP1CC VKORC1
Entrez ID		2805	83862
HPRD ID		00687	15543
Ensembl ID		ENSG00000120053
Uniprot IDs		B7Z1I2 B7Z7E9 P17174	Q9BXJ8
PDB IDs		3II0
Enriched GO Terms of Interacting Partners?		Alkanesulfonate Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Activation Of Phospholipase A2 Activity Positive Regulation Of Phospholipase A2 Activity Response To Cobalamin Response To UV-A Response To Hydroxyisoflavone Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Sulfur Compound Metabolic Process Positive Regulation Of Catenin Import Into Nucleus	Positive Regulation Of Histone H3-K36 Methylation Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Fumarate Metabolic Process Glycerol Biosynthetic Process Cellular Carbohydrate Metabolic Process Aspartate Catabolic Process Glutamate Catabolic Process Vitamin K Metabolic Process Aspartate Metabolic Process Chorion Development L-methionine Biosynthetic Process From Methylthioadenosine L-methionine Salvage Response To Radiation Dicarboxylic Acid Catabolic Process Peptidyl-glutamic Acid Carboxylation Fatty Acid Homeostasis Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Histone H3-K4 Methylation 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Methionine Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Initiation Methionine Metabolic Process Triglyceride Catabolic Process Small Molecule Metabolic Process Positive Regulation Of Histone Acetylation Sulfur Amino Acid Biosynthetic Process Regulation Of DNA-templated Transcription, Initiation Entrainment Of Circadian Clock By Photoperiod Regulation Of Histone H3-K4 Methylation Glutamate Metabolic Process Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Isotype Switching Positive Regulation Of Protein Acetylation Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Polyamine Metabolic Process Glycerol Metabolic Process Histone H3-K4 Methylation Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Quinone Metabolic Process Adipose Tissue Development Positive Regulation Of Histone Methylation Drug Metabolic Process Positive Regulation Of Immunoglobulin Production Sulfur Amino Acid Metabolic Process
Tagcloud ?		aqp3 aqp9 aquaporin cancerous cbm comprehensively constraint counter g6pc gk glucogenic gluconeogenesis glutamic glycerol glycolysis hgp imposed initiates oxaloacetic pck2 pentose portray ppp represses shunted statuses supplying transaminase transcriptomic
Tagcloud (Difference) ?		aqp3 aqp9 aquaporin cancerous cbm comprehensively constraint counter g6pc gk glucogenic gluconeogenesis glutamic glycerol glycolysis hgp imposed initiates oxaloacetic pck2 pentose portray ppp represses shunted statuses supplying transaminase transcriptomic
Tagcloud (Intersection) ?