PC and MDH2

Number of citations of the paper that reports this interaction (PMID 8349677)
3

Data Source:
HPRD (in vitro)

		PC	MDH2
Gene Name		pyruvate carboxylase	malate dehydrogenase 2, NAD (mitochondrial)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol	Nucleus Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Biotin Carboxylase Activity Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Metal Ion Binding	L-malate Dehydrogenase Activity Protein Self-association Poly(A) RNA Binding Malate Dehydrogenase (NADP+) Activity
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Pyruvate Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process Lipid Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Pathogenesis Small Molecule Metabolic Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process Internal Protein Amino Acid Acetylation NADH Metabolic Process Pathogenesis Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Gluconeogenesis Glucose metabolism Defective AMN causes hereditary megaloblastic anemia 1 Myoclonic epilepsy of Lafora Glycogen storage diseases Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Metabolism of carbohydrates Biotin transport and metabolism Defects in vitamin and cofactor metabolism	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of carbohydrates Citric acid cycle (TCA cycle)
Drugs		Pyruvic acid Biotin 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL	NADH Citric Acid
Diseases
GWAS		Bipolar disorder ( 21926972) HIV-1 susceptibility ( 22174851)
Protein-Protein Interactions		3 interactors: GOT1 GOT2 MDH2	7 interactors: CRYAB CS FH GOT2 NDUFS1 PC WARS
Entrez ID		5091	4191
HPRD ID		02032	01099
Ensembl ID		ENSG00000173599	ENSG00000146701
Uniprot IDs		P11498	B3KTM1 B4DE44 E9PDB2 G3XAL0 P40926
PDB IDs		3BG3 3BG9	2DFD
Enriched GO Terms of Interacting Partners?		Oxaloacetate Metabolic Process Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Gluconeogenesis Hexose Biosynthetic Process Fumarate Metabolic Process Aspartate Catabolic Process Dicarboxylic Acid Metabolic Process Glutamate Catabolic Process Glucose Metabolic Process Aspartate Metabolic Process Carbohydrate Biosynthetic Process Pathogenesis Hexose Metabolic Process Dicarboxylic Acid Catabolic Process Monosaccharide Metabolic Process 2-oxoglutarate Metabolic Process Glutamate Metabolic Process Cellular Amino Acid Catabolic Process Carboxylic Acid Metabolic Process Carbohydrate Metabolic Process Cellular Amino Acid Biosynthetic Process Organic Acid Metabolic Process Carboxylic Acid Catabolic Process Cellular Carbohydrate Metabolic Process Glycerol Biosynthetic Process Alpha-amino Acid Metabolic Process 4-hydroxyproline Catabolic Process L-kynurenine Metabolic Process Small Molecule Metabolic Process L-methionine Biosynthetic Process From Methylthioadenosine Cellular Amino Acid Metabolic Process L-methionine Salvage Kynurenine Metabolic Process Fatty Acid Homeostasis NADH Metabolic Process Malate Metabolic Process Methionine Biosynthetic Process Methionine Metabolic Process 4-hydroxyproline Metabolic Process Cellular Modified Amino Acid Catabolic Process Sulfur Amino Acid Biosynthetic Process Polyamine Metabolic Process Glycerol Metabolic Process Tricarboxylic Acid Cycle Sulfur Amino Acid Metabolic Process Citrate Metabolic Process Anion Homeostasis NAD Metabolic Process	Fumarate Metabolic Process Dicarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Oxaloacetate Metabolic Process Cellular Respiration Tricarboxylic Acid Cycle Energy Derivation By Oxidation Of Organic Compounds Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Gluconeogenesis Aerobic Respiration Hexose Biosynthetic Process Generation Of Precursor Metabolites And Energy Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Tryptophanyl-tRNA Aminoacylation Glucose Metabolic Process Carbohydrate Biosynthetic Process Aspartate Catabolic Process 4-hydroxyproline Catabolic Process L-kynurenine Metabolic Process Pathogenesis Hexose Metabolic Process Glutamate Catabolic Process Aspartate Metabolic Process Tubulin Complex Assembly Monosaccharide Metabolic Process Carbohydrate Metabolic Process Cellular Metabolic Process Biotin Metabolic Process Kynurenine Metabolic Process Dicarboxylic Acid Catabolic Process 2-oxoglutarate Metabolic Process Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation 4-hydroxyproline Metabolic Process Cellular Modified Amino Acid Catabolic Process Apoptotic Process Involved In Development Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Oxidation-reduction Process Regulation Of Mitochondrial Membrane Potential Developmental Programmed Cell Death Microtubule Polymerization Or Depolymerization Monocarboxylic Acid Metabolic Process Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Reactive Oxygen Species Metabolic Process
Tagcloud ?		47d accordance acetyltransferase ar ara70 bridging caf classic cloning coactivator coactivators coordinate cos deduced differs du ele1 ele1alpha ele1beta glucocorticoid gr hela isoform leucine lncap nonallelic rfg steroid testis tfiib	aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Difference) ?		47d accordance acetyltransferase ar ara70 bridging caf classic cloning coactivator coactivators coordinate cos deduced differs du ele1 ele1alpha ele1beta glucocorticoid gr hela isoform leucine lncap nonallelic rfg steroid testis tfiib	aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Intersection) ?