NPPB and NPR3

Number of citations of the paper that reports this interaction (PMID 1672777)
65

Data Source:
BioGRID (pull down, x-ray crystallography)
HPRD (in vitro, in vivo)

		NPPB	NPR3
Gene Name		natriuretic peptide B	natriuretic peptide receptor 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Protein Complex	Integral Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Hormone Activity Diuretic Hormone Activity	G-protein Coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding Protein Homodimerization Activity
	Biological Process	CGMP Biosynthetic Process Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Regulation Of Vasodilation Regulation Of Vascular Permeability Regulation Of Blood Vessel Size	Skeletal System Development Osteoclast Proliferation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Pressure Pancreatic Juice Secretion Regulation Of Osteoblast Proliferation Positive Regulation Of Urine Volume Phosphatidylinositol-mediated Signaling Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Activity
Pathways
Drugs		Carvedilol
Diseases
GWAS		Blood pressure ( 21909110) Systolic blood pressure ( 19430483)	Blood pressure ( 21572416 21909110) Diastolic blood pressure ( 21909115) Height ( 20881960 19343178 23563607 19570815) Hypertension ( 21909115) Ovarian reserve ( 22116950) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		10 interactors: EWSR1 HDAC4 KRT40 KRTAP10-3 KRTAP10-9 NOTCH2NL NPR1 NPR2 NPR3 PSMA3	3 interactors: NPPA NPPB NPPC
Entrez ID		4879	4883
HPRD ID		08974	00167
Ensembl ID		ENSG00000120937	ENSG00000113389
Uniprot IDs		P16860	A8K4A5 C9JK69 P17342 Q60I31
PDB IDs		1YK1 3N56	1JDN 1JDP 1YK0 1YK1
Enriched GO Terms of Interacting Partners?		Receptor Guanylyl Cyclase Signaling Pathway Positive Regulation Of Urine Volume CGMP Biosynthetic Process Regulation Of Blood Pressure CGMP Metabolic Process Intracellular Signal Transduction Cyclic Purine Nucleotide Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Blood Circulation Cyclic Nucleotide Biosynthetic Process Cyclic Nucleotide Metabolic Process Renal System Process Regulation Of Smooth Muscle Cell Proliferation Body Fluid Secretion Skeletal System Development Signal Transduction Negative Regulation Of Cell Proliferation Negative Regulation Of Oocyte Maturation Signaling Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Cell Communication Negative Regulation Of Oocyte Development Osteoclast Proliferation Pancreatic Juice Secretion Negative Regulation Of Glycolytic Process Peptidyl-lysine Deacetylation Response To Denervation Involved In Regulation Of Muscle Adaptation Cellular Response To Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Ossification Response To Inactivity Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Protein Sumoylation Positive Regulation Of CGMP Biosynthetic Process Regulation Of Skeletal Muscle Fiber Development Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of CGMP Metabolic Process Regulation Of Protein Sumoylation Negative Regulation Of Striated Muscle Cell Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Adenylate Cyclase Activity Regulation Of Renal Sodium Excretion	Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Cyclic Nucleotide Biosynthetic Process Regulation Of Blood Vessel Size Regulation Of Tube Size Cyclic Nucleotide Metabolic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Blood Circulation Ribose Phosphate Metabolic Process Regulation Of Vasodilation Nucleotide Metabolic Process Regulation Of Growth Nucleobase-containing Small Molecule Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Organophosphate Metabolic Process Negative Regulation Of Cell Growth Regulation Of Blood Pressure Growth Plate Cartilage Chondrocyte Proliferation Negative Regulation Of Growth Negative Regulation Of Oocyte Maturation Response To Hypoxia Regulation Of Generation Of L-type Calcium Current Positive Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Oocyte Development Regulation Of Cell Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Cardiac Muscle Contraction Growth Plate Cartilage Chondrocyte Differentiation Small Molecule Metabolic Process Regulation Of Delayed Rectifier Potassium Channel Activity Response To Muscle Stretch Positive Regulation Of Striated Muscle Contraction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Renal Sodium Excretion Phosphate-containing Compound Metabolic Process Positive Regulation Of Urine Volume Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of CGMP Biosynthetic Process Cardiac Muscle Hypertrophy In Response To Stress Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of CGMP Metabolic Process Growth Plate Cartilage Development
Tagcloud ?		0x10 18x10 75x10 americans ancestry architecture arr blacks bnp cardioprotective checked cogent consortium copies directions dosages echogen gwa imputed klkb1 logarithmically lvm motivate natriuretic relations residuals rs198389 rs3733402 whites	atherogenic cip1 cnp cytoprotective exerting facet gpcrs huvec innovative ischaemic kip1 ko m372049 mitogenesis myocardium natriuretic pd98059 pertussis raosmc reversing salvaging smooth umbilical underlies vasculature vasoprotective vasorelaxant waf1
Tagcloud (Difference) ?		0x10 18x10 75x10 americans ancestry architecture arr blacks bnp cardioprotective checked cogent consortium copies directions dosages echogen gwa imputed klkb1 logarithmically lvm motivate relations residuals rs198389 rs3733402 whites	atherogenic cip1 cnp cytoprotective exerting facet gpcrs huvec innovative ischaemic kip1 ko m372049 mitogenesis myocardium pd98059 pertussis raosmc reversing salvaging smooth umbilical underlies vasculature vasoprotective vasorelaxant waf1
Tagcloud (Intersection) ?		natriuretic