NPPB and NPR1

Number of citations of the paper that reports this interaction (PMID 1309330)
45

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		NPPB	NPR1
Gene Name		natriuretic peptide B	natriuretic peptide receptor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Protein Complex	Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Receptor Binding Hormone Activity Diuretic Hormone Activity	Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding G-protein Coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Protein Kinase Binding Hormone Binding
	Biological Process	CGMP Biosynthetic Process Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Regulation Of Vasodilation Regulation Of Vascular Permeability Regulation Of Blood Vessel Size	CGMP Biosynthetic Process Protein Phosphorylation Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway G-protein Coupled Receptor Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth Positive Regulation Of CGMP Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Regulation Of Vasodilation Dopamine Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Vessel Size
Pathways
Drugs		Carvedilol	Nitroprusside Nitroglycerin Isosorbide Dinitrate Amyl Nitrite Erythrityl Tetranitrate Nesiritide
Diseases
GWAS		Blood pressure ( 21909110) Systolic blood pressure ( 19430483)
Protein-Protein Interactions		10 interactors: EWSR1 HDAC4 KRT40 KRTAP10-3 KRTAP10-9 NOTCH2NL NPR1 NPR2 NPR3 PSMA3	5 interactors: ATF7IP NPPA NPPB NPPC PRKG1
Entrez ID		4879	4881
HPRD ID		08974	00165
Ensembl ID		ENSG00000120937	ENSG00000169418
Uniprot IDs		P16860	P16066
PDB IDs		1YK1 3N56
Enriched GO Terms of Interacting Partners?		Receptor Guanylyl Cyclase Signaling Pathway Positive Regulation Of Urine Volume CGMP Biosynthetic Process Regulation Of Blood Pressure CGMP Metabolic Process Intracellular Signal Transduction Cyclic Purine Nucleotide Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Blood Circulation Cyclic Nucleotide Biosynthetic Process Cyclic Nucleotide Metabolic Process Renal System Process Regulation Of Smooth Muscle Cell Proliferation Body Fluid Secretion Skeletal System Development Signal Transduction Negative Regulation Of Cell Proliferation Negative Regulation Of Oocyte Maturation Signaling Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Cell Communication Negative Regulation Of Oocyte Development Osteoclast Proliferation Pancreatic Juice Secretion Negative Regulation Of Glycolytic Process Peptidyl-lysine Deacetylation Response To Denervation Involved In Regulation Of Muscle Adaptation Cellular Response To Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Ossification Response To Inactivity Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Protein Sumoylation Positive Regulation Of CGMP Biosynthetic Process Regulation Of Skeletal Muscle Fiber Development Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of CGMP Metabolic Process Regulation Of Protein Sumoylation Negative Regulation Of Striated Muscle Cell Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Adenylate Cyclase Activity Regulation Of Renal Sodium Excretion	Regulation Of Blood Vessel Size Regulation Of Tube Size Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Cyclic Nucleotide Biosynthetic Process Blood Circulation Cyclic Nucleotide Metabolic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Regulation Of Vasodilation Nucleotide Metabolic Process Regulation Of Growth Nucleobase-containing Small Molecule Metabolic Process Growth Plate Cartilage Chondrocyte Proliferation Negative Regulation Of Cell Growth Regulation Of Muscle Contraction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Blood Pressure Negative Regulation Of Oocyte Maturation Organophosphate Metabolic Process Regulation Of Generation Of L-type Calcium Current Positive Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Oocyte Development Phosphate-containing Compound Metabolic Process Negative Regulation Of Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Muscle System Process Growth Plate Cartilage Chondrocyte Differentiation Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Cardiac Muscle Contraction Response To Hypoxia Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of Delayed Rectifier Potassium Channel Activity Response To Muscle Stretch Relaxation Of Vascular Smooth Muscle Regulation Of Cell Growth CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Platelet Aggregation Positive Regulation Of Striated Muscle Contraction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Urine Volume
Tagcloud ?		0x10 18x10 75x10 americans ancestry architecture arr blacks bnp cardioprotective checked cogent consortium copies directions dosages echogen gwa imputed klkb1 logarithmically lvm motivate natriuretic relations residuals rs198389 rs3733402 whites	advantages asset bands bzip complemented elusive ethylene interacting interested isolating offers overexpressing oxylipin powerful proteolytically pull purification purifying researchers salicylic stimulus tag tagged tagging tap tga2 tga5 tga6 xenobiotic
Tagcloud (Difference) ?		0x10 18x10 75x10 americans ancestry architecture arr blacks bnp cardioprotective checked cogent consortium copies directions dosages echogen gwa imputed klkb1 logarithmically lvm motivate natriuretic relations residuals rs198389 rs3733402 whites	advantages asset bands bzip complemented elusive ethylene interacting interested isolating offers overexpressing oxylipin powerful proteolytically pull purification purifying researchers salicylic stimulus tag tagged tagging tap tga2 tga5 tga6 xenobiotic
Tagcloud (Intersection) ?