NPR3

Gene Name		natriuretic peptide receptor 3
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Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding Protein Homodimerization Activity
	Biological Process	Skeletal System Development Osteoclast Proliferation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Pressure Pancreatic Juice Secretion Regulation Of Osteoblast Proliferation Positive Regulation Of Urine Volume Phosphatidylinositol-mediated Signaling Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Activity
Pathways
Drugs
Diseases
GWAS		Blood pressure ( 21572416 21909110) Diastolic blood pressure ( 21909115) Height ( 20881960 19343178 23563607 19570815) Hypertension ( 21909115) Ovarian reserve ( 22116950) Systolic blood pressure ( 21909115)
Protein-protein Interactions		3 interactors: NPPA NPPB NPPC
Entrez ID		4883
HPRD ID		00167
Ensembl ID		ENSG00000113389
Uniprot IDs		A8K4A5 C9JK69 P17342 Q60I31
PDB IDs		1JDN 1JDP 1YK0 1YK1
Enriched GO Terms of Interacting Partners?		Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Cyclic Nucleotide Biosynthetic Process Regulation Of Blood Vessel Size Regulation Of Tube Size Cyclic Nucleotide Metabolic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Blood Circulation Ribose Phosphate Metabolic Process Regulation Of Vasodilation Nucleotide Metabolic Process Regulation Of Growth Nucleobase-containing Small Molecule Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Organophosphate Metabolic Process Negative Regulation Of Cell Growth Regulation Of Blood Pressure Growth Plate Cartilage Chondrocyte Proliferation Negative Regulation Of Growth Negative Regulation Of Oocyte Maturation Response To Hypoxia Regulation Of Generation Of L-type Calcium Current Positive Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Oocyte Development Regulation Of Cell Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Cardiac Muscle Contraction Growth Plate Cartilage Chondrocyte Differentiation Small Molecule Metabolic Process Regulation Of Delayed Rectifier Potassium Channel Activity Response To Muscle Stretch Positive Regulation Of Striated Muscle Contraction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Renal Sodium Excretion Phosphate-containing Compound Metabolic Process Positive Regulation Of Urine Volume Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of CGMP Biosynthetic Process Cardiac Muscle Hypertrophy In Response To Stress Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of CGMP Metabolic Process Growth Plate Cartilage Development
Tagcloud ?		atherogenic cip1 cnp cytoprotective exerting facet gpcrs huvec innovative ischaemic kip1 ko m372049 mitogenesis myocardium natriuretic pd98059 pertussis raosmc reversing salvaging smooth umbilical underlies vasculature vasoprotective vasorelaxant waf1