LRP1 and MMP15

Number of citations of the paper that reports this interaction (PMID 14645246)
21

Data Source:
HPRD (in vitro)

		LRP1	MMP15
Gene Name		low density lipoprotein receptor-related protein 1	matrix metallopeptidase 15 (membrane-inserted)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Matrix
	Molecular Function	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding	Metalloendopeptidase Activity Calcium Ion Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding
	Biological Process	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Cellular Protein Modification Process Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Response To Estradiol Endodermal Cell Differentiation Positive Regulation Of Catalytic Activity
Pathways		Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport	Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)	Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	1 interactors: LRP1
Entrez ID		4035	4324
HPRD ID		00138	03775
Ensembl ID		ENSG00000123384	ENSG00000102996
Uniprot IDs		Q07954 Q59FG2	P51511
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell	Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Phospholipase A2 Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cholesterol Efflux Positive Regulation Of Cholesterol Transport Lipoprotein Transport Regulation Of Cholesterol Efflux Aorta Morphogenesis Aorta Development Apoptotic Cell Clearance Regulation Of Cholesterol Transport Regulation Of Smooth Muscle Cell Migration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Artery Morphogenesis Positive Regulation Of Lipid Transport Artery Development Phototransduction, Visible Light Retinoid Metabolic Process Regulation Of Phospholipase Activity Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Sterol Metabolic Process Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Migration Negative Regulation Of Neuron Death Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Regulation Of Neuron Apoptotic Process Negative Regulation Of Locomotion Steroid Metabolic Process Phagocytosis Regulation Of Neuron Death Regulation Of Wnt Signaling Pathway Aging Positive Regulation Of Protein Transport Response To Light Stimulus Alcohol Metabolic Process Receptor-mediated Endocytosis Regulation Of Actin Cytoskeleton Organization
Tagcloud ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	aldh1a1 amls carrying chemo clearance confers d835 dominated duplication effectors expanded flt3 fms immunodeficiency initiating itd jak3 leukemias lics myeloblasts nonobese recapitulated relapsed sorafenib subclones thirteen transplanted twelve twice
Tagcloud (Difference) ?		aacr an2 ang4043 angiopep bbb biologics bt conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	aldh1a1 amls carrying chemo clearance d835 dominated duplication effectors expanded flt3 fms immunodeficiency initiating itd jak3 leukemias lics myeloblasts nonobese recapitulated relapsed sorafenib subclones thirteen transplanted twelve twice
Tagcloud (Intersection) ?		confers