LRP1 and DAB2

Number of citations of the paper that reports this interaction (PMID 11247302)
80

Data Source:
BioGRID (pull down)

		LRP1	DAB2
Gene Name		low density lipoprotein receptor-related protein 1	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Nucleolus Lysosomal Membrane Plasma Membrane Coated Pit Focal Adhesion Apical Plasma Membrane Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle Transforming Growth Factor Beta Receptor Homodimeric Complex Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding	Integrin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding
	Biological Process	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Cell Morphogenesis Involved In Differentiation In Utero Embryonic Development Positive Regulation Of Receptor Recycling Positive Regulation Of Protein Phosphorylation Receptor-mediated Endocytosis Pinocytosis Apoptotic Process Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity Endoderm Development Excretion Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Protein Transport Wnt Signaling Pathway Myeloid Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Clathrin Coat Assembly Positive Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Androgen Receptor Signaling Pathway Membrane Organization Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport	Formation of annular gap junctions Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)	Chronic kidney disease ( 20383146) Pancreatic cancer ( 22158540) Urate levels ( 23263486)
Protein-Protein Interactions		63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	37 interactors: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 DYT10 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SMAD2 SMAD3 SMURF2 SRC TGFBR1 TGFBR2
Entrez ID		4035	1601
HPRD ID		00138	03139
Ensembl ID		ENSG00000123384	ENSG00000153071
Uniprot IDs		Q07954 Q59FG2	B2RAW0 P98082
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY	2LSW
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell	Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Signal Transduction Regulation Of Phosphorus Metabolic Process Negative Regulation Of Signal Transduction Signaling Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Response To Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Developmental Process Positive Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Anatomical Structure Morphogenesis Multicellular Organismal Development Wound Healing Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Nervous System Development Embryonic Morphogenesis System Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Stimulus Negative Regulation Of Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Immune System Process Anatomical Structure Development Platelet Activation
Tagcloud ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	associations blotting ccnd1 ccnd2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Difference) ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	associations blotting ccnd1 ccnd2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Intersection) ?