LRP1 and GIPC1

Number of citations of the paper that reports this interaction (PMID 10827173)
91

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		LRP1	GIPC1
Gene Name		low density lipoprotein receptor-related protein 1	GIPC PDZ domain containing family, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Endocytic Vesicle Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding	Actin Binding Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Protein Homodimerization Activity
	Biological Process	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Protein Targeting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Regulation Of Synaptic Plasticity
Pathways		Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)
Protein-Protein Interactions		63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	31 interactors: ACTN1 ADRB1 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408
Entrez ID		4035	10755
HPRD ID		00138	05462
Ensembl ID		ENSG00000123384	ENSG00000123159
Uniprot IDs		Q07954 Q59FG2	A8K2I7 O14908
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell	Response To External Stimulus Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Cell Surface Receptor Signaling Pathway Cell Communication System Development Regulation Of CAMP Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Anatomical Structure Development Positive Regulation Of Metabolic Process Developmental Process Cognition Regulation Of CAMP Metabolic Process Signaling Regulation Of Signal Transduction Signal Transduction Multicellular Organismal Development Movement Of Cell Or Subcellular Component Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Learning Or Memory Cell Migration Negative Regulation Of Signal Transduction Activation Of Adenylate Cyclase Activity Anatomical Structure Morphogenesis Regulation Of Cell Development Response To Radiation Tissue Development Cellular Response To Stimulus Regulation Of Synaptic Transmission Cell Motility Regulation Of Apoptotic Process Negative Regulation Of Signaling Positive Regulation Of Adenylate Cyclase Activity Organ Development Response To Stimulus Response To Wounding Positive Regulation Of Cell Development Cell Morphogenesis Involved In Differentiation Response To Light Stimulus Positive Regulation Of Protein Phosphorylation Regulation Of Cell Death Locomotion Regulation Of Cell Differentiation Nervous System Development
Tagcloud ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2
Tagcloud (Difference) ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2
Tagcloud (Intersection) ?		lrp1