LDHB and LDHA

Number of citations of the paper that reports this interaction (PMID 22863883)
15

Data Source:
BioGRID (two hybrid, biochemical)

		LDHB	LDHA
Gene Name		lactate dehydrogenase B	lactate dehydrogenase A
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Membrane Extracellular Vesicular Exosome	Nucleus Mitochondrion Cytosol Membrane Sperm Fibrous Sheath Extracellular Vesicular Exosome
	Molecular Function	L-lactate Dehydrogenase Activity Protein Binding Kinase Binding Identical Protein Binding NAD Binding	L-lactate Dehydrogenase Activity Protein Binding
	Biological Process	Lactate Metabolic Process Pyruvate Metabolic Process NAD Metabolic Process Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Pyruvate Metabolic Process Glycolytic Process Substantia Nigra Development Cellular Response To Extracellular Stimulus Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Pyruvate metabolism Abnormal metabolism in phenylketonuria Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Pyruvate metabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs		NADH Nicotinamide-Adenine-Dinucleotide 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid Oxamic Acid	NADH Nicotinamide-Adenine-Dinucleotide Etheno-Nad Nicotinamide Oxamic Acid
Diseases
GWAS			Amyloid A Levels ( 21124955)
Protein-Protein Interactions		7 interactors: CKS1B CKS2 LDHA PEX5 POT1 SUMO4 TERF1	15 interactors: ABCC9 ACD DYNLL1 HNRNPD KCNJ11 LDHB MAPK10 NDRG1 PCNA POT1 TERF1 TINF2 UPF2 XRN1 YWHAQ
Entrez ID		3945	3939
HPRD ID		01026	01025
Ensembl ID		ENSG00000111716	ENSG00000134333
Uniprot IDs		P07195 Q5U077	P00338
PDB IDs		1I0Z 1T2F	1I10 4AJP 4JNK 4M49
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Maintenance Cell Division Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Homotetramerization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Replication Protein Import Into Peroxisome Matrix, Translocation Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase Protein Import Into Peroxisome Matrix, Docking Telomere Maintenance Via Telomere Shortening Regulation Of Chromosome Organization Telomere Capping Negative Regulation Of Protein Homooligomerization Positive Regulation Of Helicase Activity Regulation Of Cell Cycle Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Protein Import Into Peroxisome Membrane Protein To Membrane Docking Mitotic Cell Cycle Phase Transition Peroxisomal Membrane Transport Cell Cycle Phase Transition Cell Cycle Process Replicative Cell Aging Negative Regulation Of Protein Oligomerization Regulation Of Catalytic Activity DNA Replication Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Negative Regulation Of Transferase Activity Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Polymerization	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Maintenance Telomere Assembly Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Negative Regulation Of DNA Replication Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of DNA Biosynthetic Process Positive Regulation Of Organelle Organization Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Telomerase Activity Regulation Of Chromosome Organization Regulation Of Organelle Organization Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process RNA-dependent DNA Replication Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of DNA Biosynthetic Process Potassium Ion Import Homeostatic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Localization To Chromosome Cellular Nitrogen Compound Metabolic Process RNA Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Chromosome Organization DNA Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Neural Nucleus Development Cell Cycle Phase Transition Positive Regulation Of Mitochondrion Organization DNA Replication Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation
Tagcloud ?		basal bimodal cancers chemotherapy datasets dehydrogenase dependence glycolytic heterogeneous highest lactate linking metabolic microarray molecularly neoadjuvant pam50 pathologic phenotypes posttreatment predict predicted predictive relapse robust scoring subtypes subtyping triple	11p 11q assignment cat chromosomes ets1 hbb homologous homology hras1 hsa hybrids ins karyotype karyotypes karyotypically loci monkey owl panels portion primate pth rodent segregation shared syntenic thy1 vi
Tagcloud (Difference) ?		basal bimodal cancers chemotherapy datasets dehydrogenase dependence glycolytic heterogeneous highest lactate linking metabolic microarray molecularly neoadjuvant pam50 pathologic phenotypes posttreatment predict predicted predictive relapse robust scoring subtypes subtyping triple	11p 11q assignment cat chromosomes ets1 hbb homologous homology hras1 hsa hybrids ins karyotype karyotypes karyotypically loci monkey owl panels portion primate pth rodent segregation shared syntenic thy1 vi
Tagcloud (Intersection) ?