LDHA and KCNJ11

Number of citations of the paper that reports this interaction (PMID 12145195)
34

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		LDHA	KCNJ11
Gene Name		lactate dehydrogenase A	potassium channel, inwardly rectifying subfamily J, member 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Membrane Sperm Fibrous Sheath Extracellular Vesicular Exosome	Nuclear Envelope Mitochondrion Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex ATP-sensitive Potassium Channel Complex Intercalated Disc T-tubule Axolemma Neuronal Cell Body Myelin Sheath Cell Body Fiber
	Molecular Function	L-lactate Dehydrogenase Activity Protein Binding	Voltage-gated Potassium Channel Activity ATP Binding Protein C-terminus Binding ATP-activated Inward Rectifier Potassium Channel Activity G-protein Activated Inward Rectifier Potassium Channel Activity Ankyrin Binding Potassium Ion Binding Heat Shock Protein Binding Ion Channel Binding
	Biological Process	Pyruvate Metabolic Process Glycolytic Process Substantia Nigra Development Cellular Response To Extracellular Stimulus Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Response To Ischemia Glucose Metabolic Process Energy Reserve Metabolic Process Synaptic Transmission Potassium Ion Import Response To Estradiol Response To ATP Response To Testosterone Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Response To Drug Small Molecule Metabolic Process Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Neurological System Process Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Potassium Ion Transmembrane Transport Positive Regulation Of Cation Channel Activity
Pathways		Pyruvate metabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Inwardly rectifying K+ channels Integration of energy metabolism ATP sensitive Potassium channels Regulation of insulin secretion Potassium Channels
Drugs		NADH Nicotinamide-Adenine-Dinucleotide Etheno-Nad Nicotinamide Oxamic Acid	Glimepiride Ibutilide Verapamil Levosimendan Glyburide Diazoxide Thiamylal
Diseases
GWAS		Amyloid A Levels ( 21124955)	Type 2 diabetes ( 18372903 17463246 17463248 17463249 19056611)
Protein-Protein Interactions		15 interactors: ABCC9 ACD DYNLL1 HNRNPD KCNJ11 LDHB MAPK10 NDRG1 PCNA POT1 TERF1 TINF2 UPF2 XRN1 YWHAQ	6 interactors: ABCC8 ABCC9 AP2M1 KCNJ2 KCNJ8 LDHA
Entrez ID		3939	3767
HPRD ID		01025	09022
Ensembl ID		ENSG00000134333	ENSG00000187486
Uniprot IDs		P00338	B2RC52 Q14654
PDB IDs		1I10 4AJP 4JNK 4M49
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Maintenance Telomere Assembly Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Negative Regulation Of DNA Replication Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of DNA Biosynthetic Process Positive Regulation Of Organelle Organization Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Telomerase Activity Regulation Of Chromosome Organization Regulation Of Organelle Organization Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process RNA-dependent DNA Replication Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of DNA Biosynthetic Process Potassium Ion Import Homeostatic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Localization To Chromosome Cellular Nitrogen Compound Metabolic Process RNA Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Chromosome Organization DNA Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Neural Nucleus Development Cell Cycle Phase Transition Positive Regulation Of Mitochondrion Organization DNA Replication Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation	Potassium Ion Import Potassium Ion Transmembrane Transport Synaptic Transmission Potassium Ion Transport Cell-cell Signaling Monovalent Inorganic Cation Transport Response To External Stimulus Metal Ion Transport Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Cell Communication Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Transmembrane Transport Ion Transport Relaxation Of Skeletal Muscle Defense Response To Virus Response To Stimulus Response To Virus Regulation Of Resting Membrane Potential Transport Cellular Potassium Ion Homeostasis Regulation Of Skeletal Muscle Contraction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization Relaxation Of Cardiac Muscle Potassium Ion Homeostasis Signaling Generation Of Precursor Metabolites And Energy Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Negative Regulation Of Protein Localization To Plasma Membrane Relaxation Of Muscle Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Magnesium Ion Transport Regulation Of Defense Response To Virus By Virus Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cellular Response To Stimulus Vasodilation Membrane Depolarization During Action Potential Response To PH Cardiac Muscle Cell Action Potential Clathrin-mediated Endocytosis Substantia Nigra Development Regulation Of Ion Transport Regulation Of Potassium Ion Transmembrane Transport
Tagcloud ?		11p 11q assignment cat chromosomes ets1 hbb homologous homology hras1 hsa hybrids ins karyotype karyotypes karyotypically loci monkey owl panels portion primate pth rodent segregation shared syntenic thy1 vi	5x10 asian cdkal1 cdkn2a cgs discriminative gwas hhex hnf1b homa igf2bp2 jazf1 kcnq1 marginally modestly nominal notch2 nri reclassification relating replicated roc slc30a8 summing t2d tcf7l2 unweighted weighted wfs1
Tagcloud (Difference) ?		11p 11q assignment cat chromosomes ets1 hbb homologous homology hras1 hsa hybrids ins karyotype karyotypes karyotypically loci monkey owl panels portion primate pth rodent segregation shared syntenic thy1 vi	5x10 asian cdkal1 cdkn2a cgs discriminative gwas hhex hnf1b homa igf2bp2 jazf1 kcnq1 marginally modestly nominal notch2 nri reclassification relating replicated roc slc30a8 summing t2d tcf7l2 unweighted weighted wfs1
Tagcloud (Intersection) ?