LDHB

Gene Name		lactate dehydrogenase B
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	L-lactate Dehydrogenase Activity Protein Binding Kinase Binding Identical Protein Binding NAD Binding
	Biological Process	Lactate Metabolic Process Pyruvate Metabolic Process NAD Metabolic Process Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Pyruvate metabolism Abnormal metabolism in phenylketonuria Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs		NADH Nicotinamide-Adenine-Dinucleotide 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid Oxamic Acid
Diseases
GWAS
Protein-protein Interactions		7 interactors: CKS1B CKS2 LDHA PEX5 POT1 SUMO4 TERF1
Entrez ID		3945
HPRD ID		01026
Ensembl ID		ENSG00000111716
Uniprot IDs		P07195 Q5U077
PDB IDs		1I0Z 1T2F
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Maintenance Cell Division Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Homotetramerization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Replication Protein Import Into Peroxisome Matrix, Translocation Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase Protein Import Into Peroxisome Matrix, Docking Telomere Maintenance Via Telomere Shortening Regulation Of Chromosome Organization Telomere Capping Negative Regulation Of Protein Homooligomerization Positive Regulation Of Helicase Activity Regulation Of Cell Cycle Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Protein Import Into Peroxisome Membrane Protein To Membrane Docking Mitotic Cell Cycle Phase Transition Peroxisomal Membrane Transport Cell Cycle Phase Transition Cell Cycle Process Replicative Cell Aging Negative Regulation Of Protein Oligomerization Regulation Of Catalytic Activity DNA Replication Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Negative Regulation Of Transferase Activity Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Polymerization
Tagcloud ?		basal bimodal cancers chemotherapy datasets dehydrogenase dependence glycolytic heterogeneous highest lactate linking metabolic microarray molecularly neoadjuvant pam50 pathologic phenotypes posttreatment predict predicted predictive relapse robust scoring subtypes subtyping triple