LDHB and CKS1B

Number of citations of the paper that reports this interaction (PMID 19786724)
4

Data Source:
BioGRID (pull down)

		LDHB	CKS1B
Gene Name		lactate dehydrogenase B	CDC28 protein kinase regulatory subunit 1B
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Membrane Extracellular Vesicular Exosome	Nucleoplasm
	Molecular Function	L-lactate Dehydrogenase Activity Protein Binding Kinase Binding Identical Protein Binding NAD Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Lactate Metabolic Process Pyruvate Metabolic Process NAD Metabolic Process Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cell Proliferation Cell Division
Pathways		Pyruvate metabolism Abnormal metabolism in phenylketonuria Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Cyclin D associated events in G1 SCF(Skp2)-mediated degradation of p27/p21 G1/S Transition G1 Phase Cyclin E associated events during G1/S transition SCF(Skp2)-mediated degradation of p27/p21 S Phase Cyclin A:Cdk2-associated events at S phase entry Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs		NADH Nicotinamide-Adenine-Dinucleotide 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid Oxamic Acid
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		7 interactors: CKS1B CKS2 LDHA PEX5 POT1 SUMO4 TERF1	34 interactors: ARID5A CCNA1 CCNA2 CCNB2 CDC27 CDC37 CDK1 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CUL1 DUSP1 HSP90AA1 IKZF1 KIAA0368 KRTAP10-9 KRTAP5-9 LDHB MEOX1 MIPOL1 PSMD9 REL ROPN1 SEPT3 SKP1 SKP2 SPERT SSBP1 SUMO1P1 TCF4 TRIM27 XIAP
Entrez ID		3945	1163
HPRD ID		01026	00299
Ensembl ID		ENSG00000111716	ENSG00000173207
Uniprot IDs		P07195 Q5U077	P61024 Q5T178
PDB IDs		1I0Z 1T2F	1BUH 1DKS 1DKT 2ASS 2AST
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Maintenance Cell Division Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Homotetramerization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Replication Protein Import Into Peroxisome Matrix, Translocation Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase Protein Import Into Peroxisome Matrix, Docking Telomere Maintenance Via Telomere Shortening Regulation Of Chromosome Organization Telomere Capping Negative Regulation Of Protein Homooligomerization Positive Regulation Of Helicase Activity Regulation Of Cell Cycle Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Protein Import Into Peroxisome Membrane Protein To Membrane Docking Mitotic Cell Cycle Phase Transition Peroxisomal Membrane Transport Cell Cycle Phase Transition Cell Cycle Process Replicative Cell Aging Negative Regulation Of Protein Oligomerization Regulation Of Catalytic Activity DNA Replication Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Negative Regulation Of Transferase Activity Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Polymerization	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Cell Division Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Checkpoint Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Mitotic DNA Damage Checkpoint Regulation Of Protein Kinase Activity Mitotic DNA Integrity Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Kinase Activity Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		basal bimodal cancers chemotherapy datasets dehydrogenase dependence glycolytic heterogeneous highest lactate linking metabolic microarray molecularly neoadjuvant pam50 pathologic phenotypes posttreatment predict predicted predictive relapse robust scoring subtypes subtyping triple	axis biomarker cascade chemoresistance chemoresistant discoveries doi drive escape exerts gained immunoinhibitory inversely l1 l1highdrug mechanistic microrna mimic mir mt nsclc pd platinum programmed promotion sensitizes stat3 tumorigenicity worse
Tagcloud (Difference) ?		basal bimodal cancers chemotherapy datasets dehydrogenase dependence glycolytic heterogeneous highest lactate linking metabolic microarray molecularly neoadjuvant pam50 pathologic phenotypes posttreatment predict predicted predictive relapse robust scoring subtypes subtyping triple	axis biomarker cascade chemoresistance chemoresistant discoveries doi drive escape exerts gained immunoinhibitory inversely l1 l1highdrug mechanistic microrna mimic mir mt nsclc pd platinum programmed promotion sensitizes stat3 tumorigenicity worse
Tagcloud (Intersection) ?