KRT1 and MBL2

Number of citations of the paper that reports this interaction (PMID 11549596)
24

Data Source:
HPRD (in vivo)

		KRT1	MBL2
Gene Name		keratin 1, type II	mannose-binding lectin (protein C) 2, soluble
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoskeleton Plasma Membrane Membrane Extracellular Matrix Keratin Filament Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Collagen Trimer Extracellular Space Cell Surface
	Molecular Function	Receptor Activity Structural Molecule Activity Protein Binding Carbohydrate Binding	Receptor Binding Calcium Ion Binding Protein Binding Mannose Binding Calcium-dependent Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Fibrinolysis Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Establishment Of Skin Barrier	Complement Activation, Lectin Pathway Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Defense Response To Bacterium Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Negative Regulation Of Viral Process Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Killing By Host Of Symbiont Cells
Pathways			Creation of C4 and C2 activators Complement cascade Initial triggering of complement Lectin pathway of complement activation Innate Immune System
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23326517) Bone mineral density ( 22504420)
Protein-Protein Interactions		15 interactors: CALB2 CSTA DSP EVPL F12 FANCA FANCC IVL KNG1 KRT5 LOR MBL2 PI3 PRKCE YWHAQ	8 interactors: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC
Entrez ID		3848	4153
HPRD ID		00763	01107
Ensembl ID		ENSG00000167768	ENSG00000165471
Uniprot IDs		P04264	P11226 Q5SQS3
PDB IDs			1HUP
Enriched GO Terms of Interacting Partners?		Peptide Cross-linking Keratinocyte Differentiation Epidermis Development Epidermal Cell Differentiation Skin Development Keratinization Epithelial Cell Differentiation Epithelium Development Blood Coagulation, Intrinsic Pathway Regulation Of Wound Healing Regulation Of Protein Processing Protein Activation Cascade Cytosolic Calcium Ion Homeostasis Tissue Development Positive Regulation Of Wound Healing Wound Healing Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Peptidase Activity Negative Regulation Of Coagulation Positive Regulation Of Cellular Glucuronidation Response To Wounding Cellular Calcium Ion Homeostasis Negative Regulation Of Wound Healing Calcium Ion Homeostasis Positive Regulation Of Transport Anatomical Structure Development Acute Inflammatory Response Organ Development Negative Regulation Of Proteolysis Ventricular Compact Myocardium Morphogenesis Factor XII Activation TRAM-dependent Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Regulation Of Blood Coagulation Negative Regulation Of Hydrolase Activity Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Blood Coagulation Inflammatory Response Developmental Process Hemostasis Protein Metabolic Process Cellular Cation Homeostasis Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Localization To Adherens Junction Positive Regulation Of Fibrinolysis Cellular Ion Homeostasis Response To Stress	Complement Activation, Lectin Pathway Positive Regulation Of Immune System Process Complement Activation Immune System Process Protein Activation Cascade Regulation Of Immune System Process Positive Regulation Of Immune Response Endocytosis Humoral Immune Response Cellular Calcium Ion Homeostasis Regulation Of Immune Response Chemical Homeostasis Calcium Ion Homeostasis Negative Regulation Of Protein Metabolic Process Regulation Of Humoral Immune Response Receptor-mediated Endocytosis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Peptide Antigen Assembly With MHC Class I Protein Complex Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Defense Response Homeostatic Process Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Ion Homeostasis Vesicle-mediated Transport Negative Regulation Of Immune Response Positive Regulation Of DNA Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Homeostasis Negative Regulation Of APC-Cdc20 Complex Activity Sequestering Of Calcium Ion Cytosolic Calcium Ion Homeostasis Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of T Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Spindle Checkpoint Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Response To Stress Glucocorticoid Receptor Signaling Pathway Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Cell Division Positive Regulation Of Gamma-delta T Cell Differentiation
Tagcloud ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional jup keratin kinds linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	32p alkali arises cytoskeletal detergent distinctive encode enzymatic heavily incubation insoluble labelled lstra membranous mo moloney momulv mulv murine phosphoproteins phosphorylate pp60src reflecting sarcoma shares transformed transforming view viruses
Tagcloud (Difference) ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional jup keratin kinds linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	32p alkali arises cytoskeletal detergent distinctive encode enzymatic heavily incubation insoluble labelled lstra membranous mo moloney momulv mulv murine phosphoproteins phosphorylate pp60src reflecting sarcoma shares transformed transforming view viruses
Tagcloud (Intersection) ?