KEL and TUBA1A

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		KEL	TUBA1A
Gene Name		Kell blood group, metallo-endopeptidase	tubulin, alpha 1a
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Nucleus Cytosol Microtubule Cytoplasmic Microtubule Cytoplasmic Ribonucleoprotein Granule Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding
	Biological Process	Proteolysis Cellular Calcium Ion Homeostasis Regulation Of Cell Size Cellular Magnesium Ion Homeostasis Regulation Of Axon Diameter Vasoconstriction Myelination Skeletal Muscle Fiber Development Negative Regulation Of Potassium Ion Transmembrane Transport	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Folding Organelle Organization Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Cell Division
Pathways			Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane L1CAM interactions G2/M Transition Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Regulation of PLK1 Activity at G2/M Transition Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs			Albendazole Vinblastine Mebendazole Epothilone D Epothilone B 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS
Protein-Protein Interactions		7 interactors: EDN1 EDN2 EDN3 EWSR1 TUBA1A UBC XK	53 interactors: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CLIP1 CNP CXCR1 CYLD DAG1 DUSP23 EGFR GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LRRK2 MAP2 MAPK6 MAPRE1 MAX MYC NFATC1 NUDT3 PAFAH1B1 PFDN1 PLA2G7 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPG20 STARD13 SYK TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70
Entrez ID		3792	7846
HPRD ID		00194	03959
Ensembl ID		ENSG00000197993	ENSG00000167552
Uniprot IDs		P23276	Q71U36
PDB IDs
Enriched GO Terms of Interacting Partners?		Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vascular Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Positive Regulation Of Heart Rate Positive Regulation Of Heart Contraction Vasoconstriction Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Regulation Of Vasoconstriction Smooth Muscle Contraction Positive Regulation Of Leukocyte Chemotaxis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Heart Rate Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Positive Regulation Of Leukocyte Migration Tonic Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure Cellular Metal Ion Homeostasis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cellular Cation Homeostasis Cellular Ion Homeostasis Positive Regulation Of Behavior Metal Ion Homeostasis Regulation Of Chemotaxis Second-messenger-mediated Signaling Cellular Chemical Homeostasis Magnesium Ion Homeostasis Ion Homeostasis Regulation Of Heart Contraction Cellular Response To Cytokine Stimulus Regulation Of Blood Pressure Regulation Of Behavior Prostaglandin Biosynthetic Process Cellular Homeostasis Positive Regulation Of MAP Kinase Activity Response To Cytokine Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Cell Cycle Process Prostaglandin Metabolic Process Muscle System Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Oxidoreductase Activity Chemical Homeostasis Positive Regulation Of Cell Cycle	Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cell Communication Cell Death Death Intracellular Signal Transduction Signaling Programmed Cell Death Response To Stimulus Response To Organic Substance Positive Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Response To Stress Regulation Of Cellular Component Organization Negative Regulation Of Phosphorylation Apoptotic Process Developmental Process Cell Cycle Regulation Of Intracellular Transport System Development Regulation Of Intracellular Signal Transduction Defense Response Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Organic Substance Cellular Process Negative Regulation Of Intracellular Signal Transduction Locomotion Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Immune System Process Anatomical Structure Development Signal Transduction Regulation Of Phosphorylation Regulation Of Cell Death Immune Response-regulating Signaling Pathway Neuron Development Regulation Of Growth Nervous System Development Cell Differentiation Cell Development Regulation Of Kinase Activity Neuron Projection Morphogenesis Regulation Of Cellular Process Multicellular Organismal Development Innate Immune Response Cell Projection Morphogenesis Cell Migration
Tagcloud ?		abortions anomaly behave comes couples desert disequilibrium distortion epistatically fertility grc haplotypes histocompatibility hla homozygosity homozygotes immunogenetic inbreeding kummer linkage nomads reacts reproduction rt1 segregation specificities sterility tuaregs unusually	brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace transporter tubulin verified widespread
Tagcloud (Difference) ?		abortions anomaly behave comes couples desert disequilibrium distortion epistatically fertility grc haplotypes histocompatibility hla homozygosity homozygotes immunogenetic inbreeding kummer linkage nomads reacts reproduction rt1 segregation specificities sterility tuaregs unusually	brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace transporter tubulin verified widespread
Tagcloud (Intersection) ?