KEL and EDN2

Number of citations of the paper that reports this interaction (PMID 10438732)
14

Data Source:
HPRD (in vivo)

		KEL	EDN2
Gene Name		Kell blood group, metallo-endopeptidase	endothelin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding	Hormone Activity
	Biological Process	Proteolysis Cellular Calcium Ion Homeostasis Regulation Of Cell Size Cellular Magnesium Ion Homeostasis Regulation Of Axon Diameter Vasoconstriction Myelination Skeletal Muscle Fiber Development Negative Regulation Of Potassium Ion Transmembrane Transport	Prostaglandin Biosynthetic Process Temperature Homeostasis Positive Regulation Of Leukocyte Chemotaxis Hormonal Regulation Of The Force Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Cytokine-mediated Signaling Pathway Regulation Of Vasoconstriction Calcium-mediated Signaling Neutrophil Chemotaxis Macrophage Activation Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Energy Homeostasis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: EDN1 EDN2 EDN3 EWSR1 TUBA1A UBC XK	3 interactors: CMA1 KEL MME
Entrez ID		3792	1907
HPRD ID		00194	07173
Ensembl ID		ENSG00000197993	ENSG00000127129
Uniprot IDs		P23276	P20800
PDB IDs
Enriched GO Terms of Interacting Partners?		Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vascular Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Positive Regulation Of Heart Rate Positive Regulation Of Heart Contraction Vasoconstriction Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Regulation Of Vasoconstriction Smooth Muscle Contraction Positive Regulation Of Leukocyte Chemotaxis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Heart Rate Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Positive Regulation Of Leukocyte Migration Tonic Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure Cellular Metal Ion Homeostasis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cellular Cation Homeostasis Cellular Ion Homeostasis Positive Regulation Of Behavior Metal Ion Homeostasis Regulation Of Chemotaxis Second-messenger-mediated Signaling Cellular Chemical Homeostasis Magnesium Ion Homeostasis Ion Homeostasis Regulation Of Heart Contraction Cellular Response To Cytokine Stimulus Regulation Of Blood Pressure Regulation Of Behavior Prostaglandin Biosynthetic Process Cellular Homeostasis Positive Regulation Of MAP Kinase Activity Response To Cytokine Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Cell Cycle Process Prostaglandin Metabolic Process Muscle System Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Oxidoreductase Activity Chemical Homeostasis Positive Regulation Of Cell Cycle	Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Blood Circulation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Peptide Hormone Processing Regulation Of Systemic Arterial Blood Pressure Peptide Metabolic Process Interleukin-1 Beta Biosynthetic Process Regulation Of Blood Pressure Hormone Metabolic Process Proteolysis Protein Processing Cellular Amide Metabolic Process Cellular Response To UV-A Regulation Of Hormone Levels Creatinine Metabolic Process Cellular Magnesium Ion Homeostasis Response To UV-A Regulation Of Axon Diameter Cellular Response To UV-B Regulation Of Cell Projection Size Cellular Chemical Homeostasis Interleukin-1 Beta Production Negative Regulation Of Potassium Ion Transmembrane Transport Magnesium Ion Homeostasis Response To UV-B Replicative Senescence Organ Development Beta-amyloid Metabolic Process Cellular Homeostasis Negative Regulation Of Potassium Ion Transport Skeletal Muscle Fiber Development Cytokine Biosynthetic Process Myotube Cell Development Cytokine Metabolic Process Chemical Homeostasis Vasoconstriction Regulation Of Potassium Ion Transmembrane Transport System Development Negative Regulation Of Ion Transmembrane Transport Muscle Fiber Development Negative Regulation Of Transmembrane Transport Myotube Differentiation Cellular Response To UV Regulation Of Potassium Ion Transport Cellular Response To Glucose Stimulus Multicellular Organismal Development Anatomical Structure Development Cell Aging
Tagcloud ?		abortions anomaly behave comes couples desert disequilibrium distortion epistatically fertility grc haplotypes histocompatibility hla homozygosity homozygotes immunogenetic inbreeding kummer linkage nomads reacts reproduction rt1 segregation specificities sterility tuaregs unusually	albino ameliorates bright damaging dawley functioning glial gs inos lif light lux macroglial maintaining muller neuroprotective nm photoreceptors preconditioning pretreatment proper qpcr ranging red retina retinal s100beta sprague vimentin
Tagcloud (Difference) ?		abortions anomaly behave comes couples desert disequilibrium distortion epistatically fertility grc haplotypes histocompatibility hla homozygosity homozygotes immunogenetic inbreeding kummer linkage nomads reacts reproduction rt1 segregation specificities sterility tuaregs unusually	albino ameliorates bright damaging dawley functioning glial gs inos lif light lux macroglial maintaining muller neuroprotective nm photoreceptors preconditioning pretreatment proper qpcr ranging red retina retinal s100beta sprague vimentin
Tagcloud (Intersection) ?