TUBA1A and B4GALT1

Number of citations of the paper that reports this interaction (PMID 7744867)
23

Data Source:
BioGRID (pull down)

		TUBA1A	B4GALT1
Gene Name		tubulin, alpha 1a	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Microtubule Cytoplasmic Microtubule Cytoplasmic Ribonucleoprotein Granule Recycling Endosome Extracellular Vesicular Exosome	Golgi Trans Cisterna Golgi Membrane Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Desmosome Glycocalyx Filopodium Brush Border Membrane Golgi Cisterna Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Cytoskeletal Protein Binding Galactosyltransferase Activity Manganese Ion Binding UDP-galactosyltransferase Activity Protein Homodimerization Activity Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Folding Organelle Organization Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Cell Division	Epithelial Cell Development Acute Inflammatory Response Carbohydrate Metabolic Process Lactose Biosynthetic Process Galactose Metabolic Process Protein N-linked Glycosylation Cell Adhesion Notch Signaling Pathway Single Fertilization Binding Of Sperm To Zona Pellucida Penetration Of Zona Pellucida Negative Regulation Of Cell Proliferation Oligosaccharide Biosynthetic Process Pathogenesis Keratan Sulfate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Mammary Gland Development Multicellular Organism Reproduction Keratan Sulfate Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Development Of Secondary Sexual Characteristics Branching Morphogenesis Of An Epithelial Tube Leukocyte Migration Regulation Of Cellular Component Movement Regulation Of Acrosome Reaction Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Angiogenesis Involved In Wound Healing Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Pathways		Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane L1CAM interactions G2/M Transition Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Regulation of PLK1 Activity at G2/M Transition Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System	Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) Fertilization N-Glycan antennae elongation Defective CHST14 causes EDS, musculocontractural type N-glycan antennae elongation in the medial/trans-Golgi Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases Keratan sulfate biosynthesis Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Signaling by NOTCH Defective EXT2 causes exostoses 2 Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Transport to the Golgi and subsequent modification Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective PAPSS2 causes SEMD-PA Defective MAN1B1 causes MRT15 MPS IIIA - Sanfilippo syndrome A Pre-NOTCH Expression and Processing Defective ALG11 causes ALG11-CDG (CDG-1p) MPS IIIC - Sanfilippo syndrome C Pre-NOTCH Processing in Golgi Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Interaction With The Zona Pellucida
Drugs		Albendazole Vinblastine Mebendazole Epothilone D Epothilone B 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE	N-Acetyl-D-glucosamine 6-Aminohexyl-Uridine-C1,5\'-Diphosphate Di(N-Acetyl-D-Glucosamine) Uridine Diphosphate Galactose Uridine-5\'-Monophosphate 2-(N-Morpholino)-Ethanesulfonic Acid
Diseases
GWAS			IgG glycosylation ( 23382691) Urate levels ( 23263486)
Protein-Protein Interactions		53 interactors: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CLIP1 CNP CXCR1 CYLD DAG1 DUSP23 EGFR GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LRRK2 MAP2 MAPK6 MAPRE1 MAX MYC NFATC1 NUDT3 PAFAH1B1 PFDN1 PLA2G7 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPG20 STARD13 SYK TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70	6 interactors: CDK11A LALBA TFRC TUBA1A TUBA4A TUBB
Entrez ID		7846	2683
HPRD ID		03959	00659
Ensembl ID		ENSG00000167552	ENSG00000086062
Uniprot IDs		Q71U36	P15291
PDB IDs			2AE7 2AEC 2AES 2AGD 2AH9 2FY7 2FYA 2FYB 3EE5 4EE3 4EE4 4EE5 4EEA 4EEG 4EEM 4EEO 4L41
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cell Communication Cell Death Death Intracellular Signal Transduction Signaling Programmed Cell Death Response To Stimulus Response To Organic Substance Positive Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Response To Stress Regulation Of Cellular Component Organization Negative Regulation Of Phosphorylation Apoptotic Process Developmental Process Cell Cycle Regulation Of Intracellular Transport System Development Regulation Of Intracellular Signal Transduction Defense Response Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Organic Substance Cellular Process Negative Regulation Of Intracellular Signal Transduction Locomotion Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Immune System Process Anatomical Structure Development Signal Transduction Regulation Of Phosphorylation Regulation Of Cell Death Immune Response-regulating Signaling Pathway Neuron Development Regulation Of Growth Nervous System Development Cell Differentiation Cell Development Regulation Of Kinase Activity Neuron Projection Morphogenesis Regulation Of Cellular Process Multicellular Organismal Development Innate Immune Response Cell Projection Morphogenesis Cell Migration	Protein Polymerization G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Interleukin-4 Cell Cycle Process Cellular Protein Complex Assembly Response To Interleukin-4 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Microtubule Cytoskeleton Organization Cell Cycle Cellular Macromolecular Complex Assembly Lactose Biosynthetic Process Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Disaccharide Metabolic Process Protein Complex Assembly Cytoskeleton Organization Protein Folding Iron Ion Import Organelle Organization Positive Regulation Of Bone Resorption Oligosaccharide Biosynthetic Process Cell Division Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Positive Regulation Of Tissue Remodeling Transferrin Transport Leukocyte Mediated Cytotoxicity Cellular Component Assembly Cellular Response To Cytokine Stimulus Regulation Of Bone Resorption Establishment Of Localization In Cell Regulation Of Bone Remodeling Osteoclast Differentiation Response To Cytokine Oligosaccharide Metabolic Process Cellular Response To Drug Cellular Localization Regulation Of Tissue Remodeling
Tagcloud ?		brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace transporter tubulin verified widespread	acetylglucosaminyltransferase amidase antennae asparagine atp6v0a2 cdg cdgs cog7 documents fucose fucosylation galactosyltransferase glucosaminyl glycan glycans isofocusing mannosyl mgat2 n4 permethylated pngase sialidase slc35c1 transporting triantennary underglycosylation undersialylation unsolved v0
Tagcloud (Difference) ?		brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace transporter tubulin verified widespread	acetylglucosaminyltransferase amidase antennae asparagine atp6v0a2 cdg cdgs cog7 documents fucose fucosylation galactosyltransferase glucosaminyl glycan glycans isofocusing mannosyl mgat2 n4 permethylated pngase sialidase slc35c1 transporting triantennary underglycosylation undersialylation unsolved v0
Tagcloud (Intersection) ?