TUBA1A and PLA2G7

Number of citations of the paper that reports this interaction (PMID 9384577)
41

Data Source:
HPRD (in vivo, in vitro)

		TUBA1A	PLA2G7
Gene Name		tubulin, alpha 1a	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Microtubule Cytoplasmic Microtubule Cytoplasmic Ribonucleoprotein Granule Recycling Endosome Extracellular Vesicular Exosome	Extracellular Region Cytoplasm Low-density Lipoprotein Particle
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipid Binding Calcium-independent Phospholipase A2 Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Folding Organelle Organization Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Cell Division	Lipid Catabolic Process Low-density Lipoprotein Particle Remodeling Lipid Oxidation Plasma Lipoprotein Particle Oxidation Cellular Protein Metabolic Process Positive Regulation Of Inflammatory Response Positive Regulation Of Monocyte Chemotaxis
Pathways		Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane L1CAM interactions G2/M Transition Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Regulation of PLK1 Activity at G2/M Transition Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System	Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin
Drugs		Albendazole Vinblastine Mebendazole Epothilone D Epothilone B 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS			Lipoprotein-associated phospholipase A2 activity and mass ( 22003152 23118302 20442857)
Protein-Protein Interactions		53 interactors: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CLIP1 CNP CXCR1 CYLD DAG1 DUSP23 EGFR GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LRRK2 MAP2 MAPK6 MAPRE1 MAX MYC NFATC1 NUDT3 PAFAH1B1 PFDN1 PLA2G7 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPG20 STARD13 SYK TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70	1 interactors: TUBA1A
Entrez ID		7846	7941
HPRD ID		03959	03407
Ensembl ID		ENSG00000167552	ENSG00000146070
Uniprot IDs		Q71U36	Q13093
PDB IDs			3D59 3D5E 3F96 3F97 3F98 3F9C
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cell Communication Cell Death Death Intracellular Signal Transduction Signaling Programmed Cell Death Response To Stimulus Response To Organic Substance Positive Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Response To Stress Regulation Of Cellular Component Organization Negative Regulation Of Phosphorylation Apoptotic Process Developmental Process Cell Cycle Regulation Of Intracellular Transport System Development Regulation Of Intracellular Signal Transduction Defense Response Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Organic Substance Cellular Process Negative Regulation Of Intracellular Signal Transduction Locomotion Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Immune System Process Anatomical Structure Development Signal Transduction Regulation Of Phosphorylation Regulation Of Cell Death Immune Response-regulating Signaling Pathway Neuron Development Regulation Of Growth Nervous System Development Cell Differentiation Cell Development Regulation Of Kinase Activity Neuron Projection Morphogenesis Regulation Of Cellular Process Multicellular Organismal Development Innate Immune Response Cell Projection Morphogenesis Cell Migration	Cellular Response To Interleukin-4 Response To Interleukin-4 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Protein Polymerization G2/M Transition Of Mitotic Cell Cycle Cytoskeleton-dependent Intracellular Transport
Tagcloud ?		brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace transporter tubulin verified widespread	autoimmunity baff bcr bid ccbp2 cd55 chimeras cxcr7 dwell favoring governed imbalance inbred lgals1 mz niche notch2 occupation oscillates prf1 pulp rgs13 s1pr3 sjogren sphingosine splenic spn tlr3 transitional
Tagcloud (Difference) ?		brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace transporter tubulin verified widespread	autoimmunity baff bcr bid ccbp2 cd55 chimeras cxcr7 dwell favoring governed imbalance inbred lgals1 mz niche notch2 occupation oscillates prf1 pulp rgs13 s1pr3 sjogren sphingosine splenic spn tlr3 transitional
Tagcloud (Intersection) ?