KCNA2 and KCNA4

Number of citations of the paper that reports this interaction (PMID 10428084)
27

Data Source:
HPRD (in vivo, in vitro)

		KCNA2	KCNA4
Gene Name		potassium channel, voltage gated shaker related subfamily A, member 2	potassium channel, voltage gated shaker related subfamily A, member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Lamellipodium Cell Junction Axon Dendrite Lamellipodium Membrane Neuronal Cell Body Membrane Presynaptic Membrane Perikaryon Axon Terminus Juxtaparanode Region Of Axon	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Axon
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Outward Rectifier Potassium Channel Activity	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Ion Binding
	Biological Process	Potassium Ion Transport Synaptic Transmission Regulation Of Dopamine Secretion Neuronal Action Potential Sensory Perception Of Pain Optic Nerve Structural Organization Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport	Potassium Ion Transport Synaptic Transmission Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport
Pathways		Potassium Channels Voltage gated Potassium channels	Potassium Channels Voltage gated Potassium channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: CAMLG CNTNAP2 CTTN DLG1 DLG4 ETV1 KCNA3 KCNA4 KCNA5 KCNAB1 KCNAB2 NEU1 PTK2B PTPRA RHOA	16 interactors: ACTN2 CASK DLG1 DLG2 DLG3 DLG4 DLGAP1 ERBB2IP INADL KCNA2 LNX1 NDUFA4L2 NEU1 SAT1 SNTA1 SNTG1
Entrez ID		3737	3739
HPRD ID		01443	01444
Ensembl ID		ENSG00000177301	ENSG00000182255
Uniprot IDs		A8K1Z6 P16389	P22459
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Ion Transmembrane Transport Regulation Of Potassium Ion Transport Synaptic Transmission Regulation Of Ion Transport Neuron Projection Development Cell-cell Signaling Neuron Development Protein Complex Assembly Potassium Ion Transmembrane Transport Neuron Differentiation Potassium Ion Transport Cell Projection Organization Cellular Component Assembly Generation Of Neurons Neuron Projection Morphogenesis Neurogenesis Axon Guidance Regulation Of Actin Filament-based Process Cell Development Locomotion Cell Junction Assembly Positive Regulation Of Cytoskeleton Organization Signaling Cell Projection Morphogenesis Cell-cell Junction Organization Cell Part Morphogenesis Cell Communication Receptor Localization To Synapse Axonogenesis Movement Of Cell Or Subcellular Component Axon Development Regulation Of Membrane Potential Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Chemotaxis Nervous System Development Cell Morphogenesis Actin Filament-based Process Positive Regulation Of Cellular Component Biogenesis Vocalization Behavior Positive Regulation Of Actin Filament Polymerization Monovalent Inorganic Cation Transport Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Protein Polymerization Cell Differentiation Protein Localization To Synapse Cell Morphogenesis Involved In Differentiation Regulation Of Actin Cytoskeleton Organization Dendritic Spine Organization Regulation Of Ion Transmembrane Transporter Activity	Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Synaptic Transmission Establishment Or Maintenance Of Apical/basal Cell Polarity Cell-cell Signaling Receptor Clustering Regulation Of Ion Transmembrane Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Membrane Potential Nucleotide Metabolic Process Regulation Of Ion Transport Nucleobase-containing Small Molecule Metabolic Process Establishment Or Maintenance Of Cell Polarity Organophosphate Metabolic Process Protein Localization To Membrane Cell Communication Cortical Actin Cytoskeleton Organization Positive Regulation Of Potassium Ion Transport Cortical Cytoskeleton Organization Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Ion Transport Cell Junction Assembly Small Molecule Metabolic Process Cell-cell Junction Organization Muscle Contraction Tight Junction Assembly Signaling Protein Homooligomerization Muscle System Process Cellular Component Assembly Negative Regulation Of Phosphatase Activity Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Potassium Ion Transport Regulation Of Sodium Ion Transport Negative Regulation Of Dephosphorylation Apical Junction Assembly Cellular Protein Localization Positive Regulation Of Ion Transmembrane Transport Optic Nerve Structural Organization Spermidine Acetylation Basal Protein Localization Action Potential Sensory Perception Of Pain Membrane Organization Axon Guidance Regulation Of Phosphatase Activity Putrescine Catabolic Process Protein Oligomerization Cellular Localization
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