IL2RA and SNTA1

Number of citations of the paper that reports this interaction (PMID 15123239)
9

Data Source:
BioGRID (unspecified method)

		IL2RA	SNTA1
Gene Name		interleukin 2 receptor, alpha	syntrophin, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Intracellular Cytoplasm Cytoskeleton Syntrophin Complex Lateral Plasma Membrane Cell Junction Neuromuscular Junction Sarcolemma Protein Complex Postsynaptic Membrane
	Molecular Function	Interleukin-2 Receptor Activity Drug Binding Interleukin-2 Binding	Actin Binding Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Ion Channel Binding Nitric-oxide Synthase Binding ATPase Binding
	Biological Process	Inflammatory Response To Antigenic Stimulus Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Cell Proliferation Interleukin-2-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Negative Regulation Of Immune Response	Regulation Of Heart Rate Regulation Of Vasoconstriction By Circulating Norepinephrine Muscle Contraction Neuromuscular Junction Development Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Alopecia areata ( 20596022) Asthma (bronchodilator response) ( 23508266) Crohn's disease ( 21102463) Inflammatory biomarkers ( 22228203) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 19525953 19525955 17660530 21833088) Rheumatoid arthritis ( 20453842) Type 1 diabetes ( 19430480 22293688 18978792) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 20410501)
Protein-Protein Interactions		8 interactors: CD4 ICAM1 IL2 IL2RB NFKB1 SNTA1 STAT3 STAT5B	72 interactors: ABCA1 ABCC4 ACTA2 ADAMTS6 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B BAI1 BAI2 BAI3 C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA F8A1 FABP1 FAM189B GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TLX3 TRA TRBV12-3 UTRN XRCC6
Entrez ID		3559	6640
HPRD ID		00986	03009
Ensembl ID		ENSG00000134460	ENSG00000101400
Uniprot IDs		P01589 Q5W005	B4DX40 Q13424
PDB IDs		1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Death Cellular Response To Cytokine Stimulus Response To Cytokine T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Acute Inflammatory Response Regulation Of Cell Death Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Positive Regulation Of Cellular Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Interleukin-2 Negative Regulation Of Programmed Cell Death Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cytokine Biosynthetic Process Cell Surface Receptor Signaling Pathway Lymphocyte Activation Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Biosynthetic Process Cellular Response To Organonitrogen Compound Response To Bacterium Response To Ethanol Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process T Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Metabolic Process Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Viral Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Signal Transduction Response To Copper Ion Positive Regulation Of Activated T Cell Proliferation Regulation Of Immune System Process Regulation Of Interleukin-2 Biosynthetic Process Growth Hormone Receptor Signaling Pathway Defense Response Cellular Response To Growth Hormone Stimulus Regulation Of Cell Adhesion Cellular Response To Interleukin-6 Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation	Cell-cell Signaling Synaptic Transmission Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Muscle System Process Muscle Contraction Regulation Of Heart Contraction G-protein Coupled Receptor Signaling Pathway Metal Ion Transport Ion Transport Regulation Of Muscle Contraction Blood Circulation Negative Regulation Of Adrenergic Receptor Signaling Pathway Monovalent Inorganic Cation Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Cation Transport Regulation Of Striated Muscle Contraction Cell Surface Receptor Signaling Pathway Cation Transmembrane Transport Transmembrane Transport Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Homeostasis Positive Regulation Of Cell Proliferation Ion Transmembrane Transport Potassium Ion Import Regulation Of Phosphorus Metabolic Process Behavior Response To Stimulus Regulation Of Membrane Potential Positive Regulation Of Transport Regulation Of Cellular Process Regulation Of Sodium Ion Transport CGMP Metabolic Process Positive Regulation Of Ion Transport Response To Drug Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Action Potential Regulation Of Body Fluid Levels Multicellular Organismal Response To Stress Response To Stress Cellular Response To Stimulus
Tagcloud ?		artp calculating chief convergence dusp2 hrgg il6 il8ra il8rb infgr1 irf2 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound
Tagcloud (Difference) ?		artp calculating chief convergence dusp2 hrgg il6 il8ra il8rb infgr1 irf2 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound
Tagcloud (Intersection) ?