IL2RA and STAT3

Number of citations of the paper that reports this interaction (PMID 10602027)
5

Data Source:
HPRD (in vivo)

		IL2RA	STAT3
Gene Name		interleukin 2 receptor, alpha	signal transducer and activator of transcription 3 (acute-phase response factor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane
	Molecular Function	Interleukin-2 Receptor Activity Drug Binding Interleukin-2 Binding	RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Phosphatase Binding CCR5 Chemokine Receptor Binding Glucocorticoid Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity
	Biological Process	Inflammatory Response To Antigenic Stimulus Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Cell Proliferation Interleukin-2-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Negative Regulation Of Immune Response	Negative Regulation Of Transcription From RNA Polymerase II Promoter Temperature Homeostasis Eye Photoreceptor Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Import Into Nucleus Movement Of Cell Or Subcellular Component Acute-phase Response Signal Transduction JAK-STAT Cascade Nervous System Development Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Phosphorylation Cytokine-mediated Signaling Pathway Sexual Reproduction Intracellular Receptor Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Somatic Stem Cell Maintenance Regulation Of Multicellular Organism Growth Response To Drug Glucose Homeostasis Eating Behavior Response To Ethanol Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Astrocyte Differentiation Radial Glial Cell Differentiation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Negative Regulation Of Cell Death Interleukin-6-mediated Signaling Pathway Negative Regulation Of Neuron Migration
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by PDGF Signalling by NGF Signaling by FGFR in disease Cellular Senescence Interleukin-6 signaling Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by SCF-KIT Signaling by Interleukins Transcriptional regulation of pluripotent stem cells Downstream signal transduction Signaling by FGFR1 mutants Signalling to STAT3 Signaling by FGFR mutants Signaling by FGFR1 fusion mutants POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by Leptin Growth hormone receptor signaling
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Alopecia areata ( 20596022) Asthma (bronchodilator response) ( 23508266) Crohn's disease ( 21102463) Inflammatory biomarkers ( 22228203) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 19525953 19525955 17660530 21833088) Rheumatoid arthritis ( 20453842) Type 1 diabetes ( 19430480 22293688 18978792) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 20410501)	Crohn's disease ( 18587394 21102463 23266558) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 21833088 20159113)
Protein-Protein Interactions		8 interactors: CD4 ICAM1 IL2 IL2RB NFKB1 SNTA1 STAT3 STAT5B	161 interactors: ADRB2 AMBP AR ARFIP2 ASXL1 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 CAPN1 CAPNS1 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBB2IP FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GATA1 GATA2 GHR GNB2L1 GNL3 GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HIC1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL22RA1 IL23R IL2RA IL2RB IL6R IL6ST IL7R IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KPNA1 KPNA6 LAMB2 LCK LEP LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MET MORC4 MRPS31 MTOR MYOD1 NCOA1 NDUFA13 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 OGDHL PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PML PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RAC1 RB1 RELA RET RPA2 RPL11 RPS6KA5 RPS9 SCAF11 SETD7 SIAH1 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 SSSCA1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TRIM28 TRIP10 TSHR TSLP ZFPM2 ZNF148 ZNF467
Entrez ID		3559	6774
HPRD ID		00986	00026
Ensembl ID		ENSG00000134460	ENSG00000168610
Uniprot IDs		P01589 Q5W005	K7ENL3 P40763
PDB IDs		1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Death Cellular Response To Cytokine Stimulus Response To Cytokine T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Acute Inflammatory Response Regulation Of Cell Death Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Positive Regulation Of Cellular Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Interleukin-2 Negative Regulation Of Programmed Cell Death Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cytokine Biosynthetic Process Cell Surface Receptor Signaling Pathway Lymphocyte Activation Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Biosynthetic Process Cellular Response To Organonitrogen Compound Response To Bacterium Response To Ethanol Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process T Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Metabolic Process Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Viral Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Signal Transduction Response To Copper Ion Positive Regulation Of Activated T Cell Proliferation Regulation Of Immune System Process Regulation Of Interleukin-2 Biosynthetic Process Growth Hormone Receptor Signaling Pathway Defense Response Cellular Response To Growth Hormone Stimulus Regulation Of Cell Adhesion Cellular Response To Interleukin-6 Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation	Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Defense Response Response To Cytokine Regulation Of Signal Transduction Immune System Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Cell Communication Signaling Positive Regulation Of Gene Expression Response To Stress Response To Stimulus Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Regulation Of Immune Response Immune Response Protein Autophosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Positive Regulation Of Cell Proliferation Positive Regulation Of Immune System Process Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Intracellular Signal Transduction Response To External Stimulus Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation
Tagcloud ?		artp calculating chief convergence dusp2 hrgg il6 il8ra il8rb infgr1 irf2 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	1r a25 ang angiotensin at1 bfgf cho constructs dependently dominant fibroblast ikappabalpha janus jun mek mek1 messengers modulators overexpress pathophysiological raf ras redox shared stat1 stimulatory transcriptionally transfection transiently tyrphostin
Tagcloud (Difference) ?		artp calculating chief convergence dusp2 hrgg il6 il8ra il8rb infgr1 irf2 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	1r a25 ang angiotensin at1 bfgf cho constructs dependently dominant fibroblast ikappabalpha janus jun mek mek1 messengers modulators overexpress pathophysiological raf ras redox shared stat1 stimulatory transcriptionally transfection transiently tyrphostin
Tagcloud (Intersection) ?