IL1A and IL1R2

Number of citations of the paper that reports this interaction (PMID 7878046)
24

Data Source:
HPRD (in vitro)

		IL1A	IL1R2
Gene Name		interleukin 1, alpha	interleukin 1 receptor, type II
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol	Extracellular Region Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding	Interleukin-1 Receptor Activity Interleukin-1, Type II, Blocking Receptor Activity Protein Binding
	Biological Process	Fever Generation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Apoptotic Process Inflammatory Response Immune Response Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Response To Copper Ion Positive Regulation Of Cytokine Secretion Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Immune Response Cytokine-mediated Signaling Pathway
Pathways		Signaling by Interleukins Interleukin-1 processing Cellular Senescence Interleukin-1 signaling Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system	Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs
Diseases
GWAS		Endometriosis ( 20844546) Working memory ( 21107309)	Ankylosing spondylitis ( 20062062) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		9 interactors: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP NDN NFKBIE S100A13	4 interactors: IL1A IL1B IL1RAP IL1RN
Entrez ID		3552	7850
HPRD ID		00988	00995
Ensembl ID			ENSG00000115590
Uniprot IDs		P01583	P27930
PDB IDs		1ITA 2ILA 2KKI 2L5X	3O4O
Enriched GO Terms of Interacting Partners?		Cytokine Production Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Immune Response Response To Cytokine Response To Organic Substance Interleukin-1 Alpha Secretion Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Autophagy D-serine Transport Mitochondrial Depolarization Positive Regulation Of Interleukin-1 Alpha Secretion Regulation Of Protein Transport Regulation Of Protein Targeting To Mitochondrion Interleukin-2 Biosynthetic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Process Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Interleukin-1 Secretion Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Interleukin-2 Production Positive Regulation Of Granulocyte Differentiation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitochondrion Degradation Regulation Of Intracellular Protein Transport Interleukin-1-mediated Signaling Pathway Regulation Of Inflammatory Response Interleukin-1 Beta Production Receptor Catabolic Process Regulation Of Cellular Localization Positive Regulation Of Actin Cytoskeleton Reorganization Respiratory System Process Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Cytoplasmic Sequestering Of Transcription Factor Cytokine Biosynthetic Process Response To Copper Ion Regulation Of Interleukin-1 Beta Secretion Axonal Fasciculation Cytoplasmic Sequestering Of Protein Positive Regulation Of Signal Transduction Response To Stimulus Mast Cell Degranulation	Fever Generation Heat Generation Temperature Homeostasis Acute-phase Response Inflammatory Response Acute Inflammatory Response Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Cytokine Ectopic Germ Cell Programmed Cell Death Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Interleukin-2 Biosynthetic Process Multicellular Organismal Homeostasis Regulation Of Interleukin-2 Biosynthetic Process Immune Response Positive Regulation Vascular Endothelial Growth Factor Production Defense Response Positive Regulation Of Interleukin-2 Production Developmental Programmed Cell Death Positive Regulation Of Mitotic Nuclear Division Regulation Of Vascular Endothelial Growth Factor Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Organic Substance Positive Regulation Of Cytokine Biosynthetic Process Cellular Response To Cytokine Stimulus Regulation Of MAPK Cascade Immune System Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Secretion Extrinsic Apoptotic Signaling Pathway Regulation Of Cytokine Biosynthetic Process Response To Organic Substance Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Nuclear Division Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Adiponectin Secretion Positive Regulation Of Myosin Light Chain Kinase Activity Positive Regulation Of Cell Division Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Phosphorylation Cytokine Production Regulation Of Anion Transport Negative Regulation Of Apoptotic Process
Tagcloud ?		45mg amenable copy curative cytokine dacomitinib eligible endpoint evaluable exploratory forty goals harboring her4 il1b il4 il6 il8 irreversible manageable p16ink4a pfs pi3k pik3ca platinum progressed recistv1 scchn shorter	30min ancestry asks asleep habitual ifng ifngr1 il10 il13 il17a il1b il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender
Tagcloud (Difference) ?		45mg amenable copy curative cytokine dacomitinib eligible endpoint evaluable exploratory forty goals harboring her4 irreversible manageable p16ink4a pfs pi3k pik3ca platinum progressed recistv1 scchn shorter	30min ancestry asks asleep habitual ifng ifngr1 il10 il13 il17a il2 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender
Tagcloud (Intersection) ?		il1b il4 il6 il8