IL1A

Gene Name		interleukin 1, alpha
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding
	Biological Process	Fever Generation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Apoptotic Process Inflammatory Response Immune Response Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Response To Copper Ion Positive Regulation Of Cytokine Secretion Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by Interleukins Interleukin-1 processing Cellular Senescence Interleukin-1 signaling Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Endometriosis ( 20844546) Working memory ( 21107309)
Protein-protein Interactions		9 interactors: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP NDN NFKBIE S100A13
Entrez ID		3552
HPRD ID		00988
Ensembl ID
Uniprot IDs		P01583
PDB IDs		1ITA 2ILA 2KKI 2L5X
Enriched GO Terms of Interacting Partners?		Cytokine Production Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Immune Response Response To Cytokine Response To Organic Substance Interleukin-1 Alpha Secretion Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Autophagy D-serine Transport Mitochondrial Depolarization Positive Regulation Of Interleukin-1 Alpha Secretion Regulation Of Protein Transport Regulation Of Protein Targeting To Mitochondrion Interleukin-2 Biosynthetic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Process Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Interleukin-1 Secretion Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Interleukin-2 Production Positive Regulation Of Granulocyte Differentiation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitochondrion Degradation Regulation Of Intracellular Protein Transport Interleukin-1-mediated Signaling Pathway Regulation Of Inflammatory Response Interleukin-1 Beta Production Receptor Catabolic Process Regulation Of Cellular Localization Positive Regulation Of Actin Cytoskeleton Reorganization Respiratory System Process Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Cytoplasmic Sequestering Of Transcription Factor Cytokine Biosynthetic Process Response To Copper Ion Regulation Of Interleukin-1 Beta Secretion Axonal Fasciculation Cytoplasmic Sequestering Of Protein Positive Regulation Of Signal Transduction Response To Stimulus Mast Cell Degranulation
Tagcloud ?		45mg amenable copy curative cytokine dacomitinib eligible endpoint evaluable exploratory forty goals harboring her4 il1b il4 il6 il8 irreversible manageable p16ink4a pfs pi3k pik3ca platinum progressed recistv1 scchn shorter