IGFBP5 and IGF2

Number of citations of the paper that reports this interaction (PMID 9497324)
15

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		IGFBP5	IGF2
Gene Name		insulin-like growth factor binding protein 5	insulin-like growth factor 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Insulin-like Growth Factor Binding Protein Complex	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Receptor Activator Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Glucose Metabolic Process Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Glucose Homeostasis Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Skeletal Muscle Tissue Growth Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Mammary Gland Involution Cellular Response To CAMP Cellular Response To Organic Cyclic Compound	Skeletal System Development Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Platelet Degranulation Glucose Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription, DNA-templated Multicellular Organismal Development Female Pregnancy Blood Coagulation Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Radiation Organ Morphogenesis Platelet Activation Exocrine Pancreas Development Response To Nutrient Levels Response To Estradiol Response To Nicotine Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Activated T Cell Proliferation Response To Drug Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Mechanical Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Receptor Activity Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	IRS-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Response to elevated platelet cytosolic Ca2+ Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R Platelet degranulation Platelet activation, signaling and aggregation IGF1R signaling cascade
Drugs
Diseases
GWAS		Thyroid hormone levels ( 23408906) Visceral fat ( 22589738)	DNA methylation (variation) ( 23725790) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Prostate cancer ( 19767753)
Protein-Protein Interactions		17 interactors: ADAM12 BAG6 F2 FHL2 FN1 IGF1 IGF2 IGFALS KPNB1 PAPPA2 PNO1 RASSF1 SERPINE1 SPP1 TF THBS1 VTN	22 interactors: BAG6 FAF1 GPC3 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 NOV PCSK4 PLG RBPMS TF VTN WISP2
Entrez ID		3488	3481
HPRD ID		00901	00939
Ensembl ID		ENSG00000115461	ENSG00000167244
Uniprot IDs		P24593	P01344
PDB IDs		1BOE 1H59	1GF2 1IGL 2L29 2V5P 3E4Z 3KR3
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Platelet Activation Blood Coagulation Hemostasis Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Exocytosis Wound Healing Regulation Of Fibrinolysis Cell Activation Response To Wounding Regulation Of Blood Coagulation Secretion By Cell Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Response To Stress Positive Regulation Of Blood Coagulation Response To Stimulus Regulation Of Wound Healing Regulation Of Cell Adhesion Secretion Positive Regulation Of Coagulation Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Protein Processing Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Regulation Of Protein Processing Negative Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Positive Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Adhesion Negative Regulation Of Coagulation Negative Regulation Of Plasminogen Activation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Wound Healing Cell Differentiation Striated Muscle Cell Differentiation Developmental Process Exocrine Pancreas Development Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase B Signaling Vesicle-mediated Transport Ossification	Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Growth Regulation Of Cellular Component Organization Regulation Of Cell Growth Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Developmental Process Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Regulation Of Signaling Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Insulin Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Carbohydrate Metabolic Process Regulation Of Cell Migration Regulation Of Phosphorylation Reproductive Process Regulation Of Cell Motility Exocrine Pancreas Development Exocrine System Development Cellular Protein Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Cellular Response To Insulin Stimulus Response To Stimulus Positive Regulation Of Protein Kinase B Signaling Cellular Response To Organonitrogen Compound Regulation Of Cellular Process Male Sex Determination Anatomical Structure Development Tissue Development Negative Regulation Of Smooth Muscle Cell Migration Protein Tetramerization Response To Insulin Response To Hormone Insulin-like Growth Factor Receptor Signaling Pathway Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Kinase B Signaling
Tagcloud ?		4h antisense autocrine benzopyran c2 igfr igfs indirectly ly294002 messenger modulated morpholinyl myoblast myoblasts p70 p70s6k persisted phenyl phosphatidylinositol pi3 prevents proliferating quiescent rapamycin s6 stably wortmaninn	affects biological blast carrying cdna cecum crossed deleted disrupted excess exclusively igf2r involve mannose must organ organs overexpressing paternal phenotypes proteolytic sdeltaigf2r sigf2r slow solely soluble stomach transgenics transmembrane
Tagcloud (Difference) ?		4h antisense autocrine benzopyran c2 igfr igfs indirectly ly294002 messenger modulated morpholinyl myoblast myoblasts p70 p70s6k persisted phenyl phosphatidylinositol pi3 prevents proliferating quiescent rapamycin s6 stably wortmaninn	affects biological blast carrying cdna cecum crossed deleted disrupted excess exclusively igf2r involve mannose must organ organs overexpressing paternal phenotypes proteolytic sdeltaigf2r sigf2r slow solely soluble stomach transgenics transmembrane
Tagcloud (Intersection) ?