IGF2 and WISP2

Number of citations of the paper that reports this interaction (PMID 10358067)
18

Data Source:
HPRD (in vitro)

		IGF2	WISP2
Gene Name		insulin-like growth factor 2	WNT1 inducible signaling pathway protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Receptor Activator Activity Protein Serine/threonine Kinase Activator Activity	Integrin Binding Insulin-like Growth Factor Binding Heparin Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Platelet Degranulation Glucose Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription, DNA-templated Multicellular Organismal Development Female Pregnancy Blood Coagulation Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Radiation Organ Morphogenesis Platelet Activation Exocrine Pancreas Development Response To Nutrient Levels Response To Estradiol Response To Nicotine Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Activated T Cell Proliferation Response To Drug Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Mechanical Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Receptor Activity Positive Regulation Of Glycogen (starch) Synthase Activity	Regulation Of Cell Growth Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Death
Pathways		IRS-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Response to elevated platelet cytosolic Ca2+ Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R Platelet degranulation Platelet activation, signaling and aggregation IGF1R signaling cascade
Drugs
Diseases
GWAS		DNA methylation (variation) ( 23725790) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Prostate cancer ( 19767753)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		22 interactors: BAG6 FAF1 GPC3 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 NOV PCSK4 PLG RBPMS TF VTN WISP2	4 interactors: HDAC1 HDAC3 IGF1 IGF2
Entrez ID		3481	8839
HPRD ID		00939	16020
Ensembl ID		ENSG00000167244	ENSG00000064205
Uniprot IDs		P01344	O76076 Q6PEG3
PDB IDs		1GF2 1IGL 2L29 2V5P 3E4Z 3KR3
Enriched GO Terms of Interacting Partners?		Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Growth Regulation Of Cellular Component Organization Regulation Of Cell Growth Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Developmental Process Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Regulation Of Signaling Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Insulin Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Carbohydrate Metabolic Process Regulation Of Cell Migration Regulation Of Phosphorylation Reproductive Process Regulation Of Cell Motility Exocrine Pancreas Development Exocrine System Development Cellular Protein Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Cellular Response To Insulin Stimulus Response To Stimulus Positive Regulation Of Protein Kinase B Signaling Cellular Response To Organonitrogen Compound Regulation Of Cellular Process Male Sex Determination Anatomical Structure Development Tissue Development Negative Regulation Of Smooth Muscle Cell Migration Protein Tetramerization Response To Insulin Response To Hormone Insulin-like Growth Factor Receptor Signaling Pathway Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Kinase B Signaling	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Exocrine Pancreas Development Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Androgen Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Histone H4 Deacetylation Positive Regulation Of Transcription, DNA-templated Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Histone H3 Deacetylation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone H3-K9 Modification Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Blood Coagulation Hemostasis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Exocrine System Development Regulation Of Transcription From RNA Polymerase II Promoter Histone Deacetylation Protein Deacetylation Platelet Degranulation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Body Fluid Levels Positive Regulation Of Protein Kinase B Signaling Wound Healing Circadian Regulation Of Gene Expression Regulation Of MAPK Cascade Positive Regulation Of T Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Pancreas Development Response To Wounding Regulation Of Multicellular Organism Growth Positive Regulation Of Protein Phosphorylation Regulation Of Glucose Metabolic Process Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		affects biological blast carrying cdna cecum crossed deleted disrupted excess exclusively igf2r involve mannose must organ organs overexpressing paternal phenotypes proteolytic sdeltaigf2r sigf2r slow solely soluble stomach transgenics transmembrane	adipocyte adipogenesis adipogenic alkaline alp axin2 black bre c3h10t1 cyanidin effectors exhibits expense glucoside inducers ingredient oryza osteogenesis osteogenic osteoporosis osteoporotic osterix ovx peonidin protect rice sativa uplc wnt
Tagcloud (Difference) ?		affects biological blast carrying cdna cecum crossed deleted disrupted excess exclusively igf2r involve mannose must organ organs overexpressing paternal phenotypes proteolytic sdeltaigf2r sigf2r slow solely soluble stomach transgenics transmembrane	adipocyte adipogenesis adipogenic alkaline alp axin2 black bre c3h10t1 cyanidin effectors exhibits expense glucoside inducers ingredient oryza osteogenesis osteogenic osteoporosis osteoporotic osterix ovx peonidin protect rice sativa uplc wnt
Tagcloud (Intersection) ?