IGF2 and GPC3

Number of citations of the paper that reports this interaction (PMID 8589713)
88

Data Source:
HPRD (in vivo)

		IGF2	GPC3
Gene Name		insulin-like growth factor 2	glypican 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Lysosomal Lumen Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Receptor Activator Activity Protein Serine/threonine Kinase Activator Activity	Protein Binding Heparan Sulfate Proteoglycan Binding Peptidyl-dipeptidase Inhibitor Activity
	Biological Process	Skeletal System Development Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Platelet Degranulation Glucose Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription, DNA-templated Multicellular Organismal Development Female Pregnancy Blood Coagulation Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Radiation Organ Morphogenesis Platelet Activation Exocrine Pancreas Development Response To Nutrient Levels Response To Estradiol Response To Nicotine Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Activated T Cell Proliferation Response To Drug Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Mechanical Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Receptor Activity Positive Regulation Of Glycogen (starch) Synthase Activity	Retinoid Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Pathogenesis Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Body Morphogenesis Negative Regulation Of Peptidase Activity Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Bone Mineralization Osteoclast Differentiation Lung Development Positive Regulation Of BMP Signaling Pathway Embryonic Hindlimb Morphogenesis Small Molecule Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Growth Positive Regulation Of Glucose Import Negative Regulation Of Epithelial Cell Proliferation Coronary Vasculature Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesonephric Duct Morphogenesis Cell Proliferation Involved In Metanephros Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		IRS-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Response to elevated platelet cytosolic Ca2+ Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R Platelet degranulation Platelet activation, signaling and aggregation IGF1R signaling cascade	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		DNA methylation (variation) ( 23725790) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Prostate cancer ( 19767753)
Protein-Protein Interactions		22 interactors: BAG6 FAF1 GPC3 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 NOV PCSK4 PLG RBPMS TF VTN WISP2	4 interactors: FGF2 IGF2 WNT3A WNT7B
Entrez ID		3481	2719
HPRD ID		00939	02074
Ensembl ID		ENSG00000167244	ENSG00000147257
Uniprot IDs		P01344	B4DTD8 I6QTG3 P51654 Q53H15
PDB IDs		1GF2 1IGL 2L29 2V5P 3E4Z 3KR3
Enriched GO Terms of Interacting Partners?		Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Growth Regulation Of Cellular Component Organization Regulation Of Cell Growth Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Developmental Process Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Regulation Of Signaling Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Insulin Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Carbohydrate Metabolic Process Regulation Of Cell Migration Regulation Of Phosphorylation Reproductive Process Regulation Of Cell Motility Exocrine Pancreas Development Exocrine System Development Cellular Protein Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Cellular Response To Insulin Stimulus Response To Stimulus Positive Regulation Of Protein Kinase B Signaling Cellular Response To Organonitrogen Compound Regulation Of Cellular Process Male Sex Determination Anatomical Structure Development Tissue Development Negative Regulation Of Smooth Muscle Cell Migration Protein Tetramerization Response To Insulin Response To Hormone Insulin-like Growth Factor Receptor Signaling Pathway Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Kinase B Signaling	Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Cell Fate Specification Positive Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Fate Commitment Organ Morphogenesis Regulation Of Cell Fate Specification Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Muscle Cell Differentiation Regulation Of Cell Fate Commitment Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Epithelial Tube Morphogenesis Positive Regulation Of Receptor Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Tube Morphogenesis Positive Regulation Of MAPK Cascade Muscle Structure Development Regulation Of Cardiac Muscle Tissue Development Morphogenesis Of An Epithelium Cellular Response To Organic Substance Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Regulation Of Cellular Protein Metabolic Process Cellular Response To Retinoic Acid Skeletal System Development Wound Healing Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Embryonic Morphogenesis Stem Cell Proliferation Tissue Morphogenesis Canonical Wnt Signaling Pathway Renal Tubule Development Response To Wounding Tube Development Regulation Of Catalytic Activity Kidney Morphogenesis
Tagcloud ?		affects biological blast carrying cdna cecum crossed deleted disrupted excess exclusively igf2r involve mannose must organ organs overexpressing paternal phenotypes proteolytic sdeltaigf2r sigf2r slow solely soluble stomach transgenics transmembrane	adulthood af amniotic band characterizing cloned declines decreasing developmental dramatically glypican immunoblot mannose midgestation mpr ontogeny parallels phosphomannan predispose preterm prominent pronounced quantitatively rodent rodents saturable see undergo wilms
Tagcloud (Difference) ?		affects biological blast carrying cdna cecum crossed deleted disrupted excess exclusively igf2r involve must organ organs overexpressing paternal phenotypes proteolytic sdeltaigf2r sigf2r slow solely soluble stomach transgenics transmembrane	adulthood af amniotic band characterizing cloned declines decreasing developmental dramatically glypican immunoblot midgestation mpr ontogeny parallels phosphomannan predispose preterm prominent pronounced quantitatively rodent rodents saturable see undergo wilms
Tagcloud (Intersection) ?		mannose