IGFBP5 and PNO1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		IGFBP5	PNO1
Gene Name		insulin-like growth factor binding protein 5	partner of NOB1 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Insulin-like Growth Factor Binding Protein Complex	Nucleus Nucleolus
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Poly(A) RNA Binding
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Glucose Metabolic Process Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Glucose Homeostasis Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Skeletal Muscle Tissue Growth Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Mammary Gland Involution Cellular Response To CAMP Cellular Response To Organic Cyclic Compound
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Thyroid hormone levels ( 23408906) Visceral fat ( 22589738)
Protein-Protein Interactions		17 interactors: ADAM12 BAG6 F2 FHL2 FN1 IGF1 IGF2 IGFALS KPNB1 PAPPA2 PNO1 RASSF1 SERPINE1 SPP1 TF THBS1 VTN	10 interactors: ATP5C1 CSNK1E FRZB GSTP1 IGFBP5 KLF6 PDPK1 RXRG SGSM2 SUPT5H
Entrez ID		3488	56902
HPRD ID		00901	14250
Ensembl ID		ENSG00000115461	ENSG00000115946
Uniprot IDs		P24593	Q9NRX1
PDB IDs		1BOE 1H59
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Platelet Activation Blood Coagulation Hemostasis Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Exocytosis Wound Healing Regulation Of Fibrinolysis Cell Activation Response To Wounding Regulation Of Blood Coagulation Secretion By Cell Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Response To Stress Positive Regulation Of Blood Coagulation Response To Stimulus Regulation Of Wound Healing Regulation Of Cell Adhesion Secretion Positive Regulation Of Coagulation Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Protein Processing Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Regulation Of Protein Processing Negative Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Positive Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Adhesion Negative Regulation Of Coagulation Negative Regulation Of Plasminogen Activation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Wound Healing Cell Differentiation Striated Muscle Cell Differentiation Developmental Process Exocrine Pancreas Development Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase B Signaling Vesicle-mediated Transport Ossification	Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Hepatocyte Differentiation Nitric Oxide Storage Cellular Response To Organic Substance Regulation Of Signaling Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Cellular Nitrogen Compound Metabolic Process Nitric Oxide Homeostasis Negative Regulation Of Monocyte Chemotactic Protein-1 Production Skeletal Muscle Tissue Growth Late Endosome To Golgi Transport Skeletal Muscle Tissue Development Common Myeloid Progenitor Cell Proliferation Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Skeletal Muscle Organ Development Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Proliferation Convergent Extension Involved In Organogenesis Mammary Gland Involution Negative Regulation Of Wnt Signaling Pathway System Development Negative Regulation Of Protein Kinase Activity Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Cellular Protein Metabolic Process Tissue Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Kinase Activity Response To Stimulus Regulation Of Intracellular Signal Transduction Organ Development Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of JUN Kinase Activity Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Striated Muscle Cell Apoptotic Process Type B Pancreatic Cell Proliferation Wnt Signaling Pathway Muscle Organ Development Regulation Of Cellular Component Organization Regulation Of Superoxide Anion Generation
Tagcloud ?		4h antisense autocrine benzopyran c2 igfr igfs indirectly ly294002 messenger modulated morpholinyl myoblast myoblasts p70 p70s6k persisted phenyl phosphatidylinositol pi3 prevents proliferating quiescent rapamycin s6 stably wortmaninn
Tagcloud (Difference) ?		4h antisense autocrine benzopyran c2 igfr igfs indirectly ly294002 messenger modulated morpholinyl myoblast myoblasts p70 p70s6k persisted phenyl phosphatidylinositol pi3 prevents proliferating quiescent rapamycin s6 stably wortmaninn
Tagcloud (Intersection) ?