DNAJA1 and CD58

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DNAJA1	CD58
Gene Name		DnaJ (Hsp40) homolog, subfamily A, member 1	CD58 molecule
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Mitochondrion Cytosol Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Binding Protein Binding ATP Binding Hsp70 Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding	Receptor Binding Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Spermatogenesis Response To Heat Sperm Motility Androgen Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Protein Refolding DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Toxin Transport	Cell Adhesion Blood Coagulation Single Organismal Cell-cell Adhesion Heterotypic Cell-cell Adhesion Leukocyte Migration Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Positive Regulation Of Interleukin-8 Secretion
Pathways			Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS			Multiple sclerosis ( 22190364 21244703 19525953 19525955 21833088)
Protein-Protein Interactions		20 interactors: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR ERG FZR1 HIVEP1 HMGCL HSPA8 LSM2 NELFCD NUDT3 PAXIP1 PTTG1 SUMO4 TM4SF1 TXN	4 interactors: APP CD2 DNAJA1 HERPUD1
Entrez ID		3301	965
HPRD ID		04159	01081
Ensembl ID		ENSG00000086061	ENSG00000116815
Uniprot IDs		P31689	P19256
PDB IDs		2LO1 2M6Y	1CCZ 1CI5 1QA9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone Acetylation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Negative Regulation Of Cellular Metabolic Process Protein K11-linked Ubiquitination Nucleobase-containing Compound Metabolic Process Protein Polyubiquitination G2 DNA Damage Checkpoint Positive Regulation Of Histone Methylation Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Acetylation Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Histone Methylation Cell Cycle Checkpoint Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of Voltage-gated Chloride Channel Activity Negative Regulation Of Fibril Organization Positive Regulation Of Histone H4-K16 Acetylation Diphosphoinositol Polyphosphate Catabolic Process Negative Regulation Of Potassium Ion Export Diadenosine Polyphosphate Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Proteasomal Protein Catabolic Process DNA Repair Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone Modification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Heart Rate By Hormone Positive Regulation Of Cellular Protein Metabolic Process	Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Myeloid Dendritic Cell Activation Response To Unfolded Protein Negative Regulation Of Protein Metabolic Process Regulation Of Protein Binding Apoptotic Process Programmed Cell Death Synaptic Growth At Neuromuscular Junction Cell Death Death Regulation Of Protein Phosphorylation Intracellular Receptor Signaling Pathway Regulation Of Protein Ubiquitination Response To Stress Collateral Sprouting In Absence Of Injury Membrane Raft Polarization Locomotion Positive Regulation Of Interferon-gamma Secretion Regulation Of Phosphorylation Regulation Of Binding Negative Regulation Of Endopeptidase Activity Collateral Sprouting Axon Midline Choice Point Recognition Membrane Raft Localization Negative Regulation Of Peptidase Activity Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Myeloid Dendritic Cell Activation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Calcium Ion Homeostasis Axon Choice Point Recognition Negative Regulation Of Proteolysis DNA Damage Response, Detection Of DNA Damage Negative Regulation Of Protein Processing Neuron Remodeling Positive Regulation Of Interleukin-8 Secretion Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Negative Regulation Of Intracellular Signal Transduction Blood Coagulation
Tagcloud ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	amixl atl bc blast burkitt cd54 cd80 cd86 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Difference) ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	amixl atl bc blast burkitt cd54 cd80 cd86 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Intersection) ?