DNAJA1 and TM4SF1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DNAJA1	TM4SF1
Gene Name		DnaJ (Hsp40) homolog, subfamily A, member 1	transmembrane 4 L six family member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Mitochondrion Cytosol Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding Protein Binding ATP Binding Hsp70 Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding	Molecular_function
	Biological Process	Protein Folding Response To Unfolded Protein Spermatogenesis Response To Heat Sperm Motility Androgen Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Protein Refolding DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Toxin Transport	Biological_process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR ERG FZR1 HIVEP1 HMGCL HSPA8 LSM2 NELFCD NUDT3 PAXIP1 PTTG1 SUMO4 TM4SF1 TXN	6 interactors: ANPEP DDR1 DNAJA1 HSPA8 SDCBP2 TUBA4A
Entrez ID		3301	4071
HPRD ID		04159	01854
Ensembl ID		ENSG00000086061	ENSG00000169908
Uniprot IDs		P31689	P30408
PDB IDs		2LO1 2M6Y
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone Acetylation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Negative Regulation Of Cellular Metabolic Process Protein K11-linked Ubiquitination Nucleobase-containing Compound Metabolic Process Protein Polyubiquitination G2 DNA Damage Checkpoint Positive Regulation Of Histone Methylation Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Acetylation Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Histone Methylation Cell Cycle Checkpoint Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of Voltage-gated Chloride Channel Activity Negative Regulation Of Fibril Organization Positive Regulation Of Histone H4-K16 Acetylation Diphosphoinositol Polyphosphate Catabolic Process Negative Regulation Of Potassium Ion Export Diadenosine Polyphosphate Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Proteasomal Protein Catabolic Process DNA Repair Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone Modification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Heart Rate By Hormone Positive Regulation Of Cellular Protein Metabolic Process	Protein Refolding Protein Folding 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Locomotion Negative Regulation Of Fibril Organization Response To Heat Secretion Response To Unfolded Protein Smooth Muscle Cell-matrix Adhesion Regulation Of Fibril Organization Response To Temperature Stimulus Cellular Protein Metabolic Process Clathrin Coat Disassembly Cellular Localization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Response To Stimulus Collagen-activated Signaling Pathway Transport DNA Damage Response, Detection Of DNA Damage Smooth Muscle Cell Migration Regulation Of Extracellular Matrix Disassembly Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Negative Regulation Of JUN Kinase Activity Protein Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Movement Of Cell Or Subcellular Component Chaperone Mediated Protein Folding Requiring Cofactor Wound Healing, Spreading Of Cells Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Extracellular Matrix Organization Response To Stress Muscle Cell Migration Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Secretion By Cell Mammary Gland Lobule Development Mammary Gland Alveolus Development Positive Regulation Of RNA Splicing Viral Process Regulation Of Cellular Response To Heat Cellular Response To Stimulus Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of JNK Cascade Regulation Of Body Fluid Levels Wound Healing Peptide Hormone Processing Negative Regulation Of Stress-activated MAPK Cascade Peptidyl-tyrosine Autophosphorylation Establishment Of Localization In Cell
Tagcloud ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	a549 adenocarcinoma ag almost blocking calu clearly consequently homologs igf1 igf1r l6 lung member mesenchymal migration overexpressing pten radiotherapy slightly tetraspanin therapeutics transmembrane tumorigenic unlike upregulated xenograft
Tagcloud (Difference) ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	a549 adenocarcinoma ag almost blocking calu clearly consequently homologs igf1 igf1r l6 lung member mesenchymal migration overexpressing pten radiotherapy slightly tetraspanin therapeutics transmembrane tumorigenic unlike upregulated xenograft
Tagcloud (Intersection) ?