HMOX2 and EIF3C

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		HMOX2	EIF3C
Gene Name		heme oxygenase (decycling) 2	eukaryotic translation initiation factor 3, subunit C
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Metal Ion Binding	Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Poly(A) RNA Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Heme Oxidation Cellular Iron Ion Homeostasis Heme Catabolic Process Small Molecule Metabolic Process Transmembrane Transport	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Iron uptake and transport Metabolism of porphyrins Heme degradation	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs		NADH
Diseases
GWAS			Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574)
Protein-Protein Interactions		32 interactors: A2M APP ATP5B BLOC1S2 CEBPZ COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 KIAA1377 LRIF1 MED31 NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746	15 interactors: AAGAB CALM1 EIF1AX EIF3E EIF3G EIF3J EIF3K HMOX2 MAPK6 NDUFA4L2 PFDN1 RPS6KA3 SMAD9 SNIP1 UBC
Entrez ID		3163	8663
HPRD ID		00783	04889
Ensembl ID		ENSG00000103415	ENSG00000184110
Uniprot IDs		I3L430 P30519	H3BRV0 Q99613
PDB IDs		2Q32 2QPP 2RGZ
Enriched GO Terms of Interacting Partners?		Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Axon Cargo Transport Cellular Macromolecule Biosynthetic Process Organelle Organization Macromolecule Biosynthetic Process RNA Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Process Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor Activity Cell Projection Organization Cellular Nitrogen Compound Metabolic Process Anterograde Axon Cargo Transport Microtubule-based Transport Positive Regulation Of Cellular Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Body Fluid Levels Cytoskeleton-dependent Intracellular Transport Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Renal Water Transport Regulation Of Cellular Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Cellular Response To CAMP Cellular Homeostasis Regulation Of Mitotic Cell Cycle Platelet Activation	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Ribonucleoprotein Complex Assembly Cellular Protein Metabolic Process Translation Ribonucleoprotein Complex Biogenesis Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Metabolic Process Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Gene Expression Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus MAPK Cascade Response To Growth Factor Intracellular Signal Transduction Cellular Macromolecular Complex Assembly Toll-like Receptor 5 Signaling Pathway Regulation Of Gene Expression Toll-like Receptor 10 Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Signal Transduction By Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Glycogen Metabolic Process Response To Hypoxia TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Polysaccharide Metabolic Process Midbrain Development Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Heme Oxidation Toll-like Receptor Signaling Pathway Central Nervous System Development Stress-activated MAPK Cascade Cellular Macromolecule Biosynthetic Process Stress-activated Protein Kinase Signaling Cascade Immune Response-regulating Signaling Pathway
Tagcloud ?			adr alternatively b16f10 deliver emphasize eukaryote eventually evolving g0 gep hct116 housekeeping hyaluronan kind lnps manipulating mcf7 nar nci polysome res retrieved rnai run seeking sirnas ubiquitously unstable vital
Tagcloud (Difference) ?			adr alternatively b16f10 deliver emphasize eukaryote eventually evolving g0 gep hct116 housekeeping hyaluronan kind lnps manipulating mcf7 nar nci polysome res retrieved rnai run seeking sirnas ubiquitously unstable vital
Tagcloud (Intersection) ?