HMOX2 and NDUFS2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		HMOX2	NDUFS2
Gene Name		heme oxygenase (decycling) 2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Metal Ion Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Carrier Activity Metal Ion Binding Quinone Binding NAD Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Heme Oxidation Cellular Iron Ion Homeostasis Heme Catabolic Process Small Molecule Metabolic Process Transmembrane Transport	Mitochondrial Electron Transport, NADH To Ubiquinone Response To Oxidative Stress Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Iron uptake and transport Metabolism of porphyrins Heme degradation	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs		NADH	NADH
Diseases
GWAS
Protein-Protein Interactions		32 interactors: A2M APP ATP5B BLOC1S2 CEBPZ COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 KIAA1377 LRIF1 MED31 NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746	5 interactors: APP CENPU EGR2 HMOX2 TNFRSF14
Entrez ID		3163	4720
HPRD ID		00783	04285
Ensembl ID		ENSG00000103415	ENSG00000158864
Uniprot IDs		I3L430 P30519	B7Z792 O75306
PDB IDs		2Q32 2QPP 2RGZ
Enriched GO Terms of Interacting Partners?		Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Axon Cargo Transport Cellular Macromolecule Biosynthetic Process Organelle Organization Macromolecule Biosynthetic Process RNA Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Process Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor Activity Cell Projection Organization Cellular Nitrogen Compound Metabolic Process Anterograde Axon Cargo Transport Microtubule-based Transport Positive Regulation Of Cellular Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Body Fluid Levels Cytoskeleton-dependent Intracellular Transport Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Renal Water Transport Regulation Of Cellular Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Cellular Response To CAMP Cellular Homeostasis Regulation Of Mitotic Cell Cycle Platelet Activation	Rhombomere 5 Formation Rhombomere 3 Formation Transition Metal Ion Homeostasis Rhombomere 3 Morphogenesis Synaptic Growth At Neuromuscular Junction Brain Segmentation Collateral Sprouting In Absence Of Injury Heme Oxidation Regulation Of Peptidyl-tyrosine Phosphorylation Rhombomere 3 Development Rhombomere 5 Development Positive Regulation Of Cytokine Secretion Involved In Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Rhombomere Morphogenesis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Learning Or Memory Axon Choice Point Recognition Locomotion Cognition Negative Regulation Of Alpha-beta T Cell Proliferation Heme Catabolic Process Neuron Remodeling Rhombomere Development Facial Nerve Structural Organization Regulation Of Cytokine Secretion Involved In Immune Response Axon Guidance Facial Nerve Morphogenesis Regulation Of Cellular Amino Acid Metabolic Process Cellular Metal Ion Homeostasis Response To Oxidative Stress Cellular Cation Homeostasis Cellular Ion Homeostasis Positive Regulation Of T Cell Migration Single-organism Behavior Metal Ion Homeostasis Cellular Copper Ion Homeostasis Response To External Stimulus Rhythmic Behavior Regulation Of T Cell Migration Parasympathetic Nervous System Development Regulation Of Cellular Ketone Metabolic Process Anatomical Structure Arrangement Copper Ion Homeostasis Suckling Behavior Axonogenesis Cellular Chemical Homeostasis Negative Regulation Of Alpha-beta T Cell Activation Viral Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?			accounting agf3l2 assembly c20orf7 c8orf38 chase confirming docks holoenzyme immunoprecipitated knock knocked labeling module mtdna nadh nd1 ndufa9 ndufaf3 ndufaf4 nucleating oxidoreductase proteolysis pulse redundant stabilizes ubiquinone
Tagcloud (Difference) ?			accounting agf3l2 assembly c20orf7 c8orf38 chase confirming docks holoenzyme immunoprecipitated knock knocked labeling module mtdna nadh nd1 ndufa9 ndufaf3 ndufaf4 nucleating oxidoreductase proteolysis pulse redundant stabilizes ubiquinone
Tagcloud (Intersection) ?