HMOX2 and SKA2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HMOX2	SKA2
Gene Name		heme oxygenase (decycling) 2	spindle and kinetochore associated complex subunit 2
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Metal Ion Binding	Protein Binding Microtubule Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Heme Oxidation Cellular Iron Ion Homeostasis Heme Catabolic Process Small Molecule Metabolic Process Transmembrane Transport	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Regulation Of Microtubule Polymerization Or Depolymerization Cell Division
Pathways		Iron uptake and transport Metabolism of porphyrins Heme degradation	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs		NADH
Diseases
GWAS			Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		32 interactors: A2M APP ATP5B BLOC1S2 CEBPZ COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 KIAA1377 LRIF1 MED31 NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746	4 interactors: HMOX2 PRKD3 SKA1 SPC24
Entrez ID		3163	348235
HPRD ID		00783	13306
Ensembl ID		ENSG00000103415	ENSG00000182628
Uniprot IDs		I3L430 P30519	J3QKN8 Q8WVK7
PDB IDs		2Q32 2QPP 2RGZ	4AJ5
Enriched GO Terms of Interacting Partners?		Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Axon Cargo Transport Cellular Macromolecule Biosynthetic Process Organelle Organization Macromolecule Biosynthetic Process RNA Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Process Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor Activity Cell Projection Organization Cellular Nitrogen Compound Metabolic Process Anterograde Axon Cargo Transport Microtubule-based Transport Positive Regulation Of Cellular Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Body Fluid Levels Cytoskeleton-dependent Intracellular Transport Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Renal Water Transport Regulation Of Cellular Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Cellular Response To CAMP Cellular Homeostasis Regulation Of Mitotic Cell Cycle Platelet Activation	Heme Oxidation Mitotic Nuclear Division Heme Catabolic Process Cell Division Mitotic Cell Cycle Process Mitotic Cell Cycle Heme Metabolic Process Porphyrin-containing Compound Metabolic Process Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway
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