HMOX2 and SNX5

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		HMOX2	SNX5
Gene Name		heme oxygenase (decycling) 2	sorting nexin 5
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Ruffle Phagocytic Cup Cytoplasmic Vesicle Membrane Retromer Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extrinsic Component Of Endosome Membrane Early Endosome Membrane Macropinocytic Cup Tubular Endosome
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Metal Ion Binding	Protein Binding Dynactin Binding Phosphatidylinositol Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Heme Oxidation Cellular Iron Ion Homeostasis Heme Catabolic Process Small Molecule Metabolic Process Transmembrane Transport	Intracellular Protein Transport Pinocytosis Vesicle Organization Retrograde Transport, Endosome To Golgi
Pathways		Iron uptake and transport Metabolism of porphyrins Heme degradation	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs		NADH
Diseases
GWAS
Protein-Protein Interactions		32 interactors: A2M APP ATP5B BLOC1S2 CEBPZ COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 KIAA1377 LRIF1 MED31 NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746	14 interactors: APPBP2 CDC37 CLTC CLTCL1 DNAJB11 FANCA HGS HMOX2 ITSN1 MESDC2 MIB1 PFDN1 PRKRA SNX2
Entrez ID		3163	27131
HPRD ID		00783	10439
Ensembl ID		ENSG00000103415	ENSG00000089006
Uniprot IDs		I3L430 P30519	Q6P5V6 Q9Y5X3
PDB IDs		2Q32 2QPP 2RGZ	1SYS
Enriched GO Terms of Interacting Partners?		Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Axon Cargo Transport Cellular Macromolecule Biosynthetic Process Organelle Organization Macromolecule Biosynthetic Process RNA Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Process Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor Activity Cell Projection Organization Cellular Nitrogen Compound Metabolic Process Anterograde Axon Cargo Transport Microtubule-based Transport Positive Regulation Of Cellular Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Body Fluid Levels Cytoskeleton-dependent Intracellular Transport Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Renal Water Transport Regulation Of Cellular Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Cellular Response To CAMP Cellular Homeostasis Regulation Of Mitotic Cell Cycle Platelet Activation	Cellular Protein Localization Intracellular Protein Transport Cellular Localization Protein Folding Endocytosis Protein Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Intracellular Transport Transport Vesicle-mediated Transport Developmental Process Negative Regulation Of Hyaluronan Biosynthetic Process Heme Oxidation Anatomical Structure Development Lamellipodium Morphogenesis
Tagcloud ?			counteracted egf egfr endosomal endosomes escrt generating ilvs intraluminal laptm4b lysosomal machineries mves neutralizes oncoprotein p2 pip pipkigammai5 promoting ptdins recruiting sorting termination transform transmembrane ubiquitinated ubiquitination vesicles vesicular
Tagcloud (Difference) ?			counteracted egf egfr endosomal endosomes escrt generating ilvs intraluminal laptm4b lysosomal machineries mves neutralizes oncoprotein p2 pip pipkigammai5 promoting ptdins recruiting sorting termination transform transmembrane ubiquitinated ubiquitination vesicles vesicular
Tagcloud (Intersection) ?