HLA-DRA and HLA-DMA

Number of citations of the paper that reports this interaction (PMID 11070170)
37

Data Source:
HPRD (in vitro, in vivo)

		HLA-DRA	HLA-DMA
Gene Name		major histocompatibility complex, class II, DR alpha	major histocompatibility complex, class II, DM alpha
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Lysosomal Membrane Multivesicular Body Cell Surface Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome
	Molecular Function	MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding	MHC Class II Protein Complex Binding
	Biological Process	Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Polysaccharide Assembly With MHC Class II Protein Complex Immune Response Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation T Cell Receptor Signaling Pathway Cognition Interferon-gamma-mediated Signaling Pathway	Peptide Antigen Assembly With MHC Class II Protein Complex Protein Transport Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Inner Ear Development Positive Regulation Of Immune Response Chaperone Mediated Protein Folding Requiring Cofactor
Pathways		Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Anti-cyclic Citrullinated Peptide Antibody ( 19287509) Asthma ( 23028483 21804548) Complement C3 and C4 levels ( 23028341) Cystic fibrosis severity ( 21602797) Hodgkin's lymphoma ( 21037568 22286212) Lymphoma ( 23349640) Multiple sclerosis ( 17660530) Multiple sclerosis (OCB status) ( 23472185) Non-obstructive azoospermia ( 22541561) Parkinson's disease ( 20711177) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Rheumatoid arthritis ( 21653640) Systemic sclerosis ( 21779181) Ulcerative colitis ( 23128233 20228798 18836448 21297633 19122664) Vitiligo ( 20410501)
Protein-Protein Interactions		10 interactors: CD63 CD74 CD82 HLA-DMA HLA-DMB HLA-DRB1 HLA-DRB5 MARCH1 MBP PRPF40B	8 interactors: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2
Entrez ID		3122	3108
HPRD ID		00833	00830
Ensembl ID		ENSG00000204287	ENSG00000204257
Uniprot IDs		P01903 Q30118	Q31604 Q5SP00 Q6ICR9
PDB IDs		1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FV1 1FYT 1H15 1HQR 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 1ZGL 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2Q6W 2SEB 2WBJ 2XN9 3C5J 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4E41 4FQX 4GBX 4H1L	4I0P
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Regulation Of Cell Adhesion Positive Regulation Of Immune Response Immune System Process Positive Thymic T Cell Selection Regulation Of Immune Response Positive Regulation Of Immune System Process Thymic T Cell Selection Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection Regulation Of Immune System Process Regulation Of Interleukin-4 Production Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Cytokine Leukocyte Mediated Immunity T Cell Selection Adaptive Immune Response 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Cellular Protein Complex Assembly Chaperone-mediated Protein Folding T Cell Costimulation T Cell Differentiation In Thymus Protein Complex Assembly Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of T Cell Differentiation Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion T Cell Receptor Signaling Pathway	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Polysaccharide Assembly With MHC Class II Protein Complex Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Cellular Protein Complex Assembly Protein Complex Assembly Immune System Process Negative Regulation Of Immune System Process T Cell Costimulation Cytokine-mediated Signaling Pathway Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion T Cell Receptor Signaling Pathway Negative Regulation Of Homotypic Cell-cell Adhesion Cellular Response To Cytokine Stimulus Positive Regulation Of Lymphocyte Proliferation Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Receptor-mediated Signaling Pathway Cellular Macromolecular Complex Assembly Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Cellular Response To Interferon-gamma Regulation Of T Cell Proliferation Response To Cytokine Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Leukocyte Activation
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