HLA-DMA and B3GAT1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HLA-DMA	B3GAT1
Gene Name		major histocompatibility complex, class II, DM alpha	beta-1,3-glucuronyltransferase 1
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Multivesicular Body Cell Surface Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome	Golgi Membrane Integral Component Of Membrane
	Molecular Function	MHC Class II Protein Complex Binding	UDP-galactose:beta-N-acetylglucosamine Beta-1,3-galactosyltransferase Activity Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Activity Metal Ion Binding
	Biological Process	Peptide Antigen Assembly With MHC Class II Protein Complex Protein Transport Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Inner Ear Development Positive Regulation Of Immune Response Chaperone Mediated Protein Folding Requiring Cofactor	Carbohydrate Metabolic Process Protein Glycosylation Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Small Molecule Metabolic Process
Pathways			MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs			D-tartaric acid Uridine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		8 interactors: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2	2 interactors: HLA-DMA SH3GL1
Entrez ID		3108	27087
HPRD ID		00830	06969
Ensembl ID		ENSG00000204257	ENSG00000109956
Uniprot IDs		Q31604 Q5SP00 Q6ICR9	F5H0S0 Q9P2W7
PDB IDs		4I0P	1V82 1V83 1V84
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Polysaccharide Assembly With MHC Class II Protein Complex Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Cellular Protein Complex Assembly Protein Complex Assembly Immune System Process Negative Regulation Of Immune System Process T Cell Costimulation Cytokine-mediated Signaling Pathway Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion T Cell Receptor Signaling Pathway Negative Regulation Of Homotypic Cell-cell Adhesion Cellular Response To Cytokine Stimulus Positive Regulation Of Lymphocyte Proliferation Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Receptor-mediated Signaling Pathway Cellular Macromolecular Complex Assembly Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Cellular Response To Interferon-gamma Regulation Of T Cell Proliferation Response To Cytokine Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Leukocyte Activation	Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Positive Thymic T Cell Selection Thymic T Cell Selection Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection T Cell Selection 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Chaperone-mediated Protein Folding T Cell Differentiation In Thymus
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