HLA-DMA and HLA-DRB1

Number of citations of the paper that reports this interaction (PMID 11070170)
37

Data Source:
HPRD (in vitro)

		HLA-DMA	HLA-DRB1
Gene Name		major histocompatibility complex, class II, DM alpha	major histocompatibility complex, class II, DR beta 1
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Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Multivesicular Body Cell Surface Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	MHC Class II Protein Complex Binding	MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Peptide Antigen Assembly With MHC Class II Protein Complex Protein Transport Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Inner Ear Development Positive Regulation Of Immune Response Chaperone Mediated Protein Folding Requiring Cofactor	Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Inflammatory Response To Antigenic Stimulus Humoral Immune Response Mediated By Circulating Immunoglobulin Peptide Antigen Assembly With MHC Class II Protein Complex Polysaccharide Assembly With MHC Class II Protein Complex Immune Response Detection Of Bacterium Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Regulation Of Interleukin-4 Production Negative Regulation Of Interferon-gamma Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T-helper 1 Type Immune Response Negative Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Protein Tetramerization Interferon-gamma-mediated Signaling Pathway Regulation Of Interleukin-10 Secretion
Pathways			Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS			Arthritis (juvenile idiopathic) ( 18576341) Cervical cancer ( 23482656) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Hepatocellular carcinoma ( 22807686) Hypothyroidism ( 22493691) IgA nephropathy ( 22197929) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A ( 20694011) Leishmaniasis (visceral) ( 23291585) Lumiracoxib-related liver injury ( 20639878) Lymphoma ( 23349640) Multiple sclerosis ( 22190364 19525953 19525955 18941528) Multiple sclerosis (OCB status) ( 23472185) Nephropathy ( 21399633) Nodular sclerosis Hodgkin lymphoma ( 22086417) Prostate cancer ( 23535732) Response to interferon beta therapy ( 21502966) Response to ximelagatran treatment ( 17505501) Rheumatoid arthritis ( 21452313 17804836 18794853 17554300 20453841 20453842) Schizophrenia ( 23212062) Systemic lupus erythematosus ( 23273568 19838193) Systemic sclerosis ( 21779181) Type 1 diabetes ( 17632545) Ulcerative colitis ( 23128233 21297633 19122664 23511034)
Protein-Protein Interactions		8 interactors: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2	9 interactors: CTAG1B HLA-DMA HLA-DRA MAGEA3 MARCH1 TRA TRB TRIM21 ZDHHC17
Entrez ID		3108	3123
HPRD ID		00830	08349
Ensembl ID		ENSG00000204257	ENSG00000196126
Uniprot IDs		Q31604 Q5SP00 Q6ICR9	D7RIH8 P01911 P01912 Q29974 Q5Y7D1
PDB IDs		4I0P	1A6A 1BX2 1YMM 2WBJ
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Polysaccharide Assembly With MHC Class II Protein Complex Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Cellular Protein Complex Assembly Protein Complex Assembly Immune System Process Negative Regulation Of Immune System Process T Cell Costimulation Cytokine-mediated Signaling Pathway Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion T Cell Receptor Signaling Pathway Negative Regulation Of Homotypic Cell-cell Adhesion Cellular Response To Cytokine Stimulus Positive Regulation Of Lymphocyte Proliferation Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Receptor-mediated Signaling Pathway Cellular Macromolecular Complex Assembly Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Cellular Response To Interferon-gamma Regulation Of T Cell Proliferation Response To Cytokine Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Leukocyte Activation	Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Interferon-gamma-mediated Signaling Pathway Immune System Process Cellular Response To Interferon-gamma Polysaccharide Assembly With MHC Class II Protein Complex Response To Interferon-gamma Protein Polyubiquitination Negative Regulation Of Protein Deubiquitination Positive Regulation Of T Cell Activation Protein Complex Assembly Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Protein Deubiquitination Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Thymic T Cell Selection Cellular Protein Complex Assembly Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Negative Regulation Of Viral Release From Host Cell Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Lipoprotein Transport Regulation Of Viral Entry Into Host Cell Magnesium Ion Transport Cellular Component Assembly Thymic T Cell Selection Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Cellular Protein Metabolic Process Response To Stimulus Protein Destabilization Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection Protein Ubiquitination Cellular Response To Cytokine Stimulus Protein Palmitoylation Protein Modification By Small Protein Conjugation Regulation Of Cell Adhesion Cellular Macromolecular Complex Assembly Positive Regulation Of Immune Response
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