HLA-DRA and HLA-DRB1

Number of citations of the paper that reports this interaction (PMID 9354468)
62

Data Source:
HPRD (in vitro)

		HLA-DRA	HLA-DRB1
Gene Name		major histocompatibility complex, class II, DR alpha	major histocompatibility complex, class II, DR beta 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding	MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Polysaccharide Assembly With MHC Class II Protein Complex Immune Response Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation T Cell Receptor Signaling Pathway Cognition Interferon-gamma-mediated Signaling Pathway	Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Inflammatory Response To Antigenic Stimulus Humoral Immune Response Mediated By Circulating Immunoglobulin Peptide Antigen Assembly With MHC Class II Protein Complex Polysaccharide Assembly With MHC Class II Protein Complex Immune Response Detection Of Bacterium Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Regulation Of Interleukin-4 Production Negative Regulation Of Interferon-gamma Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T-helper 1 Type Immune Response Negative Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Protein Tetramerization Interferon-gamma-mediated Signaling Pathway Regulation Of Interleukin-10 Secretion
Pathways		Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Anti-cyclic Citrullinated Peptide Antibody ( 19287509) Asthma ( 23028483 21804548) Complement C3 and C4 levels ( 23028341) Cystic fibrosis severity ( 21602797) Hodgkin's lymphoma ( 21037568 22286212) Lymphoma ( 23349640) Multiple sclerosis ( 17660530) Multiple sclerosis (OCB status) ( 23472185) Non-obstructive azoospermia ( 22541561) Parkinson's disease ( 20711177) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Rheumatoid arthritis ( 21653640) Systemic sclerosis ( 21779181) Ulcerative colitis ( 23128233 20228798 18836448 21297633 19122664) Vitiligo ( 20410501)	Arthritis (juvenile idiopathic) ( 18576341) Cervical cancer ( 23482656) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Hepatocellular carcinoma ( 22807686) Hypothyroidism ( 22493691) IgA nephropathy ( 22197929) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A ( 20694011) Leishmaniasis (visceral) ( 23291585) Lumiracoxib-related liver injury ( 20639878) Lymphoma ( 23349640) Multiple sclerosis ( 22190364 19525953 19525955 18941528) Multiple sclerosis (OCB status) ( 23472185) Nephropathy ( 21399633) Nodular sclerosis Hodgkin lymphoma ( 22086417) Prostate cancer ( 23535732) Response to interferon beta therapy ( 21502966) Response to ximelagatran treatment ( 17505501) Rheumatoid arthritis ( 21452313 17804836 18794853 17554300 20453841 20453842) Schizophrenia ( 23212062) Systemic lupus erythematosus ( 23273568 19838193) Systemic sclerosis ( 21779181) Type 1 diabetes ( 17632545) Ulcerative colitis ( 23128233 21297633 19122664 23511034)
Protein-Protein Interactions		10 interactors: CD63 CD74 CD82 HLA-DMA HLA-DMB HLA-DRB1 HLA-DRB5 MARCH1 MBP PRPF40B	9 interactors: CTAG1B HLA-DMA HLA-DRA MAGEA3 MARCH1 TRA TRB TRIM21 ZDHHC17
Entrez ID		3122	3123
HPRD ID		00833	08349
Ensembl ID		ENSG00000204287	ENSG00000196126
Uniprot IDs		P01903 Q30118	D7RIH8 P01911 P01912 Q29974 Q5Y7D1
PDB IDs		1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FV1 1FYT 1H15 1HQR 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 1ZGL 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2Q6W 2SEB 2WBJ 2XN9 3C5J 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4E41 4FQX 4GBX 4H1L	1A6A 1BX2 1YMM 2WBJ
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Regulation Of Cell Adhesion Positive Regulation Of Immune Response Immune System Process Positive Thymic T Cell Selection Regulation Of Immune Response Positive Regulation Of Immune System Process Thymic T Cell Selection Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection Regulation Of Immune System Process Regulation Of Interleukin-4 Production Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Cytokine Leukocyte Mediated Immunity T Cell Selection Adaptive Immune Response 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Cellular Protein Complex Assembly Chaperone-mediated Protein Folding T Cell Costimulation T Cell Differentiation In Thymus Protein Complex Assembly Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of T Cell Differentiation Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion T Cell Receptor Signaling Pathway	Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Interferon-gamma-mediated Signaling Pathway Immune System Process Cellular Response To Interferon-gamma Polysaccharide Assembly With MHC Class II Protein Complex Response To Interferon-gamma Protein Polyubiquitination Negative Regulation Of Protein Deubiquitination Positive Regulation Of T Cell Activation Protein Complex Assembly Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Protein Deubiquitination Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Thymic T Cell Selection Cellular Protein Complex Assembly Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Negative Regulation Of Viral Release From Host Cell Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Lipoprotein Transport Regulation Of Viral Entry Into Host Cell Magnesium Ion Transport Cellular Component Assembly Thymic T Cell Selection Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Cellular Protein Metabolic Process Response To Stimulus Protein Destabilization Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection Protein Ubiquitination Cellular Response To Cytokine Stimulus Protein Palmitoylation Protein Modification By Small Protein Conjugation Regulation Of Cell Adhesion Cellular Macromolecular Complex Assembly Positive Regulation Of Immune Response
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