HLA-DOA and HLA-DMA

Number of citations of the paper that reports this interaction (PMID 9311912)
37

Data Source:
HPRD (in vivo)

		HLA-DOA	HLA-DMA
Gene Name		major histocompatibility complex, class II, DO alpha	major histocompatibility complex, class II, DM alpha
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Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane MHC Class II Protein Complex	Lysosomal Membrane Multivesicular Body Cell Surface Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome
	Molecular Function	MHC Class II Protein Complex Binding MHC Class II Receptor Activity	MHC Class II Protein Complex Binding
	Biological Process	Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of T Cell Differentiation	Peptide Antigen Assembly With MHC Class II Protein Complex Protein Transport Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Inner Ear Development Positive Regulation Of Immune Response Chaperone Mediated Protein Folding Requiring Cofactor
Pathways		MHC class II antigen presentation Adaptive Immune System
Drugs
Diseases
GWAS		Asthma ( 21804548) Platelet counts ( 22139419) Wegener's granulomatosis ( 23740775)
Protein-Protein Interactions		2 interactors: HLA-DMA REL	8 interactors: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2
Entrez ID		3111	3108
HPRD ID		00837	00830
Ensembl ID		ENSG00000204252	ENSG00000204257
Uniprot IDs		B4DW77 P06340	Q31604 Q5SP00 Q6ICR9
PDB IDs		4I0P	4I0P
Enriched GO Terms of Interacting Partners?		Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Positive Thymic T Cell Selection Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Interleukin-12 Biosynthetic Process Thymic T Cell Selection Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection Immune Response NIK/NF-kappaB Signaling T Cell Selection Positive Regulation Of Interleukin-12 Production	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Polysaccharide Assembly With MHC Class II Protein Complex Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Cellular Protein Complex Assembly Protein Complex Assembly Immune System Process Negative Regulation Of Immune System Process T Cell Costimulation Cytokine-mediated Signaling Pathway Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion T Cell Receptor Signaling Pathway Negative Regulation Of Homotypic Cell-cell Adhesion Cellular Response To Cytokine Stimulus Positive Regulation Of Lymphocyte Proliferation Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Receptor-mediated Signaling Pathway Cellular Macromolecular Complex Assembly Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Cellular Response To Interferon-gamma Regulation Of T Cell Proliferation Response To Cytokine Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Leukocyte Activation
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