DNMT3B and DUSP23

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		DNMT3B	DUSP23
Gene Name		DNA (cytosine-5-)-methyltransferase 3 beta	dual specificity phosphatase 23
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Intracellular Membrane-bounded Organelle	Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Unmethylated CpG Binding Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Response To Ionizing Radiation DNA Methylation On Cytosine Within A CG Sequence Gene Expression Positive Regulation Of Gene Expression Protein Complex Localization DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Response To Drug Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine	Peptidyl-tyrosine Dephosphorylation
Pathways		NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	C-reactive protein ( 22939635) Interstitial lung disease ( 21787189)
Protein-Protein Interactions		35 interactors: BAZ2A CBX1 CBX3 CBX5 CMTM6 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS ZBTB18	24 interactors: ASB13 CCDC186 DBI DBN1 DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 KIAA1377 MKRN1 MRPL20 MTFR1 NIF3L1 PRDX4 RPL8 RUFY2 SHC1 SMPD1 TMOD3 TUBA1A ZNF746
Entrez ID		1789	54935
HPRD ID		04209	07908
Ensembl ID		ENSG00000088305	ENSG00000158716
Uniprot IDs		Q9UBC3	Q9BVJ7
PDB IDs		3FLG 3QKJ	2IMG 4ERC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process DNA Modification Chromatin Modification Chromosome Organization Chromatin Silencing Chromatin Organization Gene Silencing Nucleobase-containing Compound Metabolic Process DNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Cellular Metabolic Process Methylation Transcription, DNA-templated Histone H3-K9 Modification Chromatin Remodeling RNA Metabolic Process DNA Methylation On Cytosine Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Histone Modification Peptidyl-lysine Modification Histone H4 Deacetylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Rhythmic Process DNA Packaging Regulation Of Gene Expression By Genetic Imprinting Hypermethylation Of CpG Island C-5 Methylation Of Cytosine	Cellular Metabolic Process Organelle Organization Regulation Of Gene Expression By Genetic Imprinting Gene Expression Genetic Imprinting Positive Regulation Of Histone Methylation Negative Regulation Of Male Germ Cell Proliferation Regulation Of Histone Methylation Positive Regulation Of Protein Modification Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Positive Regulation Of Histone Modification Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Regulation Of Male Germ Cell Proliferation Dihydrobiopterin Metabolic Process Cell Communication By Chemical Coupling S-adenosylmethioninamine Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization
Tagcloud ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Difference) ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Intersection) ?