DNMT3B and CMTM6

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		DNMT3B	CMTM6
Gene Name		DNA (cytosine-5-)-methyltransferase 3 beta	CKLF-like MARVEL transmembrane domain containing 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Intracellular Membrane-bounded Organelle	Extracellular Space Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Unmethylated CpG Binding Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates	Cytokine Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Response To Ionizing Radiation DNA Methylation On Cytosine Within A CG Sequence Gene Expression Positive Regulation Of Gene Expression Protein Complex Localization DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Response To Drug Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine	Chemotaxis
Pathways		NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		35 interactors: BAZ2A CBX1 CBX3 CBX5 CMTM6 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS ZBTB18	7 interactors: ATP13A2 DNMT3B DUSP10 FAM9B PPBP SUMO2 XRCC6
Entrez ID		1789	54918
HPRD ID		04209	06987
Ensembl ID		ENSG00000088305	ENSG00000091317
Uniprot IDs		Q9UBC3	Q9NX76
PDB IDs		3FLG 3QKJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process DNA Modification Chromatin Modification Chromosome Organization Chromatin Silencing Chromatin Organization Gene Silencing Nucleobase-containing Compound Metabolic Process DNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Cellular Metabolic Process Methylation Transcription, DNA-templated Histone H3-K9 Modification Chromatin Remodeling RNA Metabolic Process DNA Methylation On Cytosine Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Histone Modification Peptidyl-lysine Modification Histone H4 Deacetylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Rhythmic Process DNA Packaging Regulation Of Gene Expression By Genetic Imprinting Hypermethylation Of CpG Island C-5 Methylation Of Cytosine	Regulation Of Neurogenesis Response To Ionizing Radiation Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Hyperosmotic Salinity Response S-adenosylmethioninamine Metabolic Process Regulation Of Cell Development DNA Methylation On Cytosine Within A CG Sequence Cellular Response To Manganese Ion Cellular Response To X-ray C-5 Methylation Of Cytosine Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation S-adenosylhomocysteine Metabolic Process Regulation Of Brown Fat Cell Differentiation Methylation-dependent Chromatin Silencing Establishment Of Integrated Proviral Latency Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Respiratory Burst Cellular Response To Salt Stress Negative Regulation Of Histone H3-K9 Methylation DNA Methylation On Cytosine Negative Regulation Of JUN Kinase Activity DNA Ligation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Neurogenesis Leukocyte Migration Involved In Inflammatory Response Response To Manganese Ion Protein Complex Localization Negative Regulation Of Histone Methylation Generation Of Neurons Regulation Of Cell Differentiation Response To Radiation Negative Regulation Of Oligodendrocyte Differentiation Double-strand Break Repair Via Nonhomologous End Joining Neurogenesis Regulation Of Histone H3-K4 Methylation Hyperosmotic Response Response To Bacterium Protein Sumoylation Positive Regulation Of Cell Development Regulation Of Gene Expression By Genetic Imprinting Hexose Transmembrane Transport V(D)J Recombination Cellular Response To Osmotic Stress Cellular Response To Stimulus Response To X-ray Negative Regulation Of JNK Cascade
Tagcloud ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Difference) ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Intersection) ?