GZMB and LMNB1

Number of citations of the paper that reports this interaction (PMID 11331782)
20

Data Source:
HPRD (in vitro)

		GZMB	LMNB1
Gene Name		granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	lamin B1
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Nucleus Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle	Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Membrane Nuclear Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Structural Molecule Activity Phospholipase Binding
	Biological Process	Proteolysis Apoptotic Process Immune Response Notch Signaling Pathway Granzyme-mediated Apoptotic Signaling Pathway Protein Processing Cytolysis Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Pathways		Signaling by NOTCH2 Signaling by NOTCH Activation, myristolyation of BID and translocation to mitochondria Programmed Cell Death NOTCH2 intracellular domain regulates transcription Intrinsic Pathway for Apoptosis	Apoptotic cleavage of cellular proteins DNA Damage/Telomere Stress Induced Senescence Mitotic Prophase Apoptotic execution phase Cellular Senescence Meiotic synapsis Depolymerisation of the Nuclear Lamina Nuclear Envelope Breakdown Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase M Phase Cell Cycle, Mitotic Formation of Senescence-Associated Heterochromatin Foci (SAHF) Programmed Cell Death Breakdown of the nuclear lamina Nuclear Envelope Reassembly Initiation of Nuclear Envelope Reformation Mitotic Metaphase and Anaphase
Drugs		Alpha-D-Mannose
Diseases
GWAS		Vitiligo ( 20410501)	Parkinson's disease (motor and cognition) ( 22658654)
Protein-Protein Interactions		26 interactors: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6	23 interactors: ABCG8 ATF4 CASP3 CASP6 CDK1 GIT2 GZMA GZMB LBR LMNA MBIP MELK PLEC PRKCA PRKCB PRKCD PRPH SERPINA3 SUMO4 TMPO TOR1AIP1 URB2 YWHAQ
Entrez ID		3002	4001
HPRD ID		00476	01036
Ensembl ID		ENSG00000100453	ENSG00000113368
Uniprot IDs		P10144 Q67BC3	B4DZT3 P20700
PDB IDs		1FQ3 1IAU	2KPW 3JT0 3TYY 3UMN
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Death Death Execution Phase Of Apoptosis Cellular Response To Stimulus Response To Stimulus Apoptotic Signaling Pathway Protein Processing Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Apoptotic Process Telomere Maintenance Glial Cell Apoptotic Process Regulation Of Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Establishment Of Integrated Proviral Latency Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Zymogen Activation Response To Abiotic Stimulus Establishment Of Viral Latency Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Signal Transduction Response To Radiation Response To Stress Positive Regulation Of Peptidase Activity Immune Response Immune System Development Double-strand Break Repair Positive Regulation Of Proteolysis Immune System Process Signaling Cellular Hyperosmotic Salinity Response Cell Communication Cellular Response To DNA Damage Stimulus Cellular Response To Stress Regulation Of Endopeptidase Activity Hemopoiesis Organ Development V(D)J Recombination Regulation Of Peptidase Activity	Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Nuclear Envelope Organization Execution Phase Of Apoptosis Apoptotic Signaling Pathway Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Nucleus Organization Peptidyl-threonine Phosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Histone H3-T6 Phosphorylation Positive Regulation Of Cell Death Cellular Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Histone Phosphorylation Peptidyl-amino Acid Modification Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Response To Oxidative Stress Positive Regulation Of Catalytic Activity Endomembrane System Organization Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of MAP Kinase Activity Regulation Of Mitochondrion Organization Regulation Of Platelet Aggregation Membrane Organization Negative Regulation Of Glucose Transport Regulation Of Phosphorylation Regulation Of MAP Kinase Activity
Tagcloud ?		adhered autonomous basement cleaved cleaves compromised constituents cremaster cytotoxic deficit destruction diapedesis ectromelia effector enabled expediting extend granzyme homing inflamed interplay intravital killer lamellipodia lymphocytes migrating null proteomic venules	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Difference) ?		adhered autonomous basement cleaved cleaves compromised constituents cremaster cytotoxic deficit destruction diapedesis ectromelia effector enabled expediting extend granzyme homing interplay intravital killer lamellipodia lymphocytes migrating null proteomic venules	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated insulitis iqgap1 lamin lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Intersection) ?		inflamed