GZMB and CASP9

Number of citations of the paper that reports this interaction (PMID 9651578)
164

Data Source:
HPRD (in vitro)

		GZMB	CASP9
Gene Name		granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	caspase 9, apoptosis-related cysteine peptidase
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Gene Ontology Annotations	Cellular Component	Immunological Synapse Nucleus Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle	Nucleus Mitochondrion Cytosol Apoptosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity SH3 Domain Binding Protein Kinase Binding
	Biological Process	Proteolysis Apoptotic Process Immune Response Notch Signaling Pathway Granzyme-mediated Apoptotic Signaling Pathway Protein Processing Cytolysis Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Proteolysis Apoptotic Process Cellular Response To DNA Damage Stimulus Epidermal Growth Factor Receptor Signaling Pathway Aging Fibroblast Growth Factor Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Platelet Formation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Cellular Response To UV Fc-epsilon Receptor Signaling Pathway Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Antibiotic Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Dexamethasone Stimulus Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Response To DNA Damage Stimulus
Pathways		Signaling by NOTCH2 Signaling by NOTCH Activation, myristolyation of BID and translocation to mitochondria Programmed Cell Death NOTCH2 intracellular domain regulates transcription Intrinsic Pathway for Apoptosis	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling SMAC binds to IAPs SMAC-mediated dissociation of IAP:caspase complexes Cytochrome c-mediated apoptotic response SMAC-mediated apoptotic response Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Role of DCC in regulating apoptosis Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome PI3K/AKT activation PI-3K cascade Apoptotic factor-mediated response NOD1/2 Signaling Pathway PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Intrinsic Pathway for Apoptosis Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Extrinsic Pathway Adaptive Immune System
Drugs		Alpha-D-Mannose
Diseases
GWAS		Vitiligo ( 20410501)
Protein-Protein Interactions		26 interactors: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6	44 interactors: ABL1 AKT1 APAF1 BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SRF VIM XIAP
Entrez ID		3002	842
HPRD ID		00476	03756
Ensembl ID		ENSG00000100453	ENSG00000132906
Uniprot IDs		P10144 Q67BC3	F8VVS7 P55211
PDB IDs		1FQ3 1IAU	1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Death Death Execution Phase Of Apoptosis Cellular Response To Stimulus Response To Stimulus Apoptotic Signaling Pathway Protein Processing Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Apoptotic Process Telomere Maintenance Glial Cell Apoptotic Process Regulation Of Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Establishment Of Integrated Proviral Latency Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Zymogen Activation Response To Abiotic Stimulus Establishment Of Viral Latency Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Signal Transduction Response To Radiation Response To Stress Positive Regulation Of Peptidase Activity Immune Response Immune System Development Double-strand Break Repair Positive Regulation Of Proteolysis Immune System Process Signaling Cellular Hyperosmotic Salinity Response Cell Communication Cellular Response To DNA Damage Stimulus Cellular Response To Stress Regulation Of Endopeptidase Activity Hemopoiesis Organ Development V(D)J Recombination Regulation Of Peptidase Activity	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Peptidase Activity Apoptotic Signaling Pathway Zymogen Activation Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Protein Processing Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Innate Immune Response Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Negative Regulation Of Cell Death
Tagcloud ?		adhered autonomous basement cleaved cleaves compromised constituents cremaster cytotoxic deficit destruction diapedesis ectromelia effector enabled expediting extend granzyme homing inflamed interplay intravital killer lamellipodia lymphocytes migrating null proteomic venules	10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp8 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y
Tagcloud (Difference) ?		adhered autonomous basement cleaved cleaves compromised constituents cremaster cytotoxic deficit destruction diapedesis ectromelia effector enabled expediting extend granzyme homing inflamed interplay intravital killer lamellipodia lymphocytes migrating null proteomic venules	10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp8 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y
Tagcloud (Intersection) ?