GZMB and UBE4B

Number of citations of the paper that reports this interaction (PMID 11802788)
6

Data Source:
HPRD (in vitro)

		GZMB	UBE4B
Gene Name		granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	ubiquitination factor E4B
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Nucleus Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Ligase Activity Enzyme Binding Ubiquitin-ubiquitin Ligase Activity
	Biological Process	Proteolysis Apoptotic Process Immune Response Notch Signaling Pathway Granzyme-mediated Apoptotic Signaling Pathway Protein Processing Cytolysis Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Granzyme-mediated Apoptotic Signaling Pathway Response To UV Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Signaling by NOTCH2 Signaling by NOTCH Activation, myristolyation of BID and translocation to mitochondria Programmed Cell Death NOTCH2 intracellular domain regulates transcription Intrinsic Pathway for Apoptosis
Drugs		Alpha-D-Mannose
Diseases
GWAS		Vitiligo ( 20410501)	Hepatocellular carcinoma ( 20676096)
Protein-Protein Interactions		26 interactors: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6	15 interactors: ATXN3 CASP3 CASP6 CASP7 CDKN2A DNAJC7 FEZ1 GZMB HGS TP53 TRIP12 UBE2D2 UBE2D3 VAV2 VCP
Entrez ID		3002	10277
HPRD ID		00476	11659
Ensembl ID		ENSG00000100453	ENSG00000130939
Uniprot IDs		P10144 Q67BC3	O95155
PDB IDs		1FQ3 1IAU	2KRE 3L1X 3L1Z
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Death Death Execution Phase Of Apoptosis Cellular Response To Stimulus Response To Stimulus Apoptotic Signaling Pathway Protein Processing Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Apoptotic Process Telomere Maintenance Glial Cell Apoptotic Process Regulation Of Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Establishment Of Integrated Proviral Latency Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Zymogen Activation Response To Abiotic Stimulus Establishment Of Viral Latency Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Signal Transduction Response To Radiation Response To Stress Positive Regulation Of Peptidase Activity Immune Response Immune System Development Double-strand Break Repair Positive Regulation Of Proteolysis Immune System Process Signaling Cellular Hyperosmotic Salinity Response Cell Communication Cellular Response To DNA Damage Stimulus Cellular Response To Stress Regulation Of Endopeptidase Activity Hemopoiesis Organ Development V(D)J Recombination Regulation Of Peptidase Activity	Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Processing Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Cellular Response To Stress Positive Regulation Of Endopeptidase Activity Apoptotic Signaling Pathway Positive Regulation Of Peptidase Activity Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Aging Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Glial Cell Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Cellular Response To DNA Damage Stimulus Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Macromolecule Catabolic Process Regulation Of Apoptotic DNA Fragmentation Ubiquitin-dependent Protein Catabolic Process Apoptotic Mitochondrial Changes Modification-dependent Protein Catabolic Process Regulation Of Apoptotic Process Execution Phase Of Apoptosis Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Cell Death Cellular Response To Growth Factor Stimulus Negative Regulation Of Macroautophagy Protein Ubiquitination DNA Repair Response To Growth Factor Protein Modification By Small Protein Conjugation DNA Metabolic Process Protein Catabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Proteolysis Response To Abiotic Stimulus Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels
Tagcloud ?		adhered autonomous basement cleaved cleaves compromised constituents cremaster cytotoxic deficit destruction diapedesis ectromelia effector enabled expediting extend granzyme homing inflamed interplay intravital killer lamellipodia lymphocytes migrating null proteomic venules	aberrantly amplified archived battery bel caspase3 cleaved colony contradictory hcc hep1 hep3b hepatocellular hepatocyte hepg2 huh7 immunohistochjemical inc lo2 oncogene periodicals resection sk smmc speculated ubiquitination undergone wiley
Tagcloud (Difference) ?		adhered autonomous basement cleaves compromised constituents cremaster cytotoxic deficit destruction diapedesis ectromelia effector enabled expediting extend granzyme homing inflamed interplay intravital killer lamellipodia lymphocytes migrating null proteomic venules	aberrantly amplified archived battery bel caspase3 colony contradictory hcc hep1 hep3b hepatocellular hepatocyte hepg2 huh7 immunohistochjemical inc lo2 oncogene periodicals resection sk smmc speculated ubiquitination undergone wiley
Tagcloud (Intersection) ?		cleaved