LMNB1 and PRPH

Number of citations of the paper that reports this interaction (PMID 1986862)
20

Data Source:
HPRD (in vitro)

		LMNB1	PRPH
Gene Name		lamin B1	peripherin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Membrane Nuclear Membrane	Intermediate Filament Neurofilament Membrane Photoreceptor Outer Segment Membrane C-fiber Type III Intermediate Filament Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity Phospholipase Binding	Structural Molecule Activity
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis	Intermediate Filament Cytoskeleton Organization
Pathways		Apoptotic cleavage of cellular proteins DNA Damage/Telomere Stress Induced Senescence Mitotic Prophase Apoptotic execution phase Cellular Senescence Meiotic synapsis Depolymerisation of the Nuclear Lamina Nuclear Envelope Breakdown Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase M Phase Cell Cycle, Mitotic Formation of Senescence-Associated Heterochromatin Foci (SAHF) Programmed Cell Death Breakdown of the nuclear lamina Nuclear Envelope Reassembly Initiation of Nuclear Envelope Reformation Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		Parkinson's disease (motor and cognition) ( 22658654)	Prostate cancer ( 21743467)
Protein-Protein Interactions		23 interactors: ABCG8 ATF4 CASP3 CASP6 CDK1 GIT2 GZMA GZMB LBR LMNA MBIP MELK PLEC PRKCA PRKCB PRKCD PRPH SERPINA3 SUMO4 TMPO TOR1AIP1 URB2 YWHAQ	5 interactors: KRT15 LMNB1 MYO5A PRPH2 VIM
Entrez ID		4001	5630
HPRD ID		01036	01365
Ensembl ID		ENSG00000113368
Uniprot IDs		B4DZT3 P20700	B3KWQ6 P41219
PDB IDs		2KPW 3JT0 3TYY 3UMN
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Nuclear Envelope Organization Execution Phase Of Apoptosis Apoptotic Signaling Pathway Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Nucleus Organization Peptidyl-threonine Phosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Histone H3-T6 Phosphorylation Positive Regulation Of Cell Death Cellular Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Histone Phosphorylation Peptidyl-amino Acid Modification Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Response To Oxidative Stress Positive Regulation Of Catalytic Activity Endomembrane System Organization Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of MAP Kinase Activity Regulation Of Mitochondrion Organization Regulation Of Platelet Aggregation Membrane Organization Negative Regulation Of Glucose Transport Regulation Of Phosphorylation Regulation Of MAP Kinase Activity	Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament-based Movement Execution Phase Of Apoptosis Tissue Development Visual Perception Sensory Perception Of Light Stimulus Endoplasmic Reticulum Localization Vesicle Transport Along Actin Filament Response To Low Light Intensity Stimulus Epithelium Development Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Locomotion Involved In Locomotory Behavior Bergmann Glial Cell Differentiation Secretory Granule Localization Camera-type Eye Development Response To Light Intensity Eye Development Long-chain Fatty Acid Biosynthetic Process Melanin Biosynthetic Process Melanin Metabolic Process Intermediate Filament Organization Lens Fiber Cell Development Secondary Metabolite Biosynthetic Process Astrocyte Development Epithelial Cell Differentiation Sensory Organ Development Muscle Filament Sliding Actin-myosin Filament Sliding Actin Filament-based Process Melanosome Transport Lens Fiber Cell Differentiation Pigment Granule Transport Anatomical Structure Development Establishment Of Melanosome Localization Melanocyte Differentiation Intermediate Filament Cytoskeleton Organization Melanosome Localization Insulin Secretion Astrocyte Differentiation Intermediate Filament-based Process Actin-mediated Cell Contraction Neuroepithelial Cell Differentiation Sensory Perception Developmental Process SMAD Protein Signal Transduction Pigment Biosynthetic Process Cellular Pigmentation Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport
Tagcloud ?		cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars	accumulated albeit autoantibodies autoreactive b c57bl dynamics epitope follicular frequencies genesis heterogeneous infiltrating insulitis invaded islet islets isotype likewise octameric peripherin peritoneum prediabetic preferentially proliferates spleen subsets switched unfolded
Tagcloud (Difference) ?		cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed iqgap1 lamin lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars	accumulated albeit autoantibodies autoreactive b c57bl dynamics epitope follicular frequencies genesis heterogeneous infiltrating invaded islet islets isotype likewise octameric peripherin peritoneum prediabetic preferentially proliferates spleen subsets switched unfolded
Tagcloud (Intersection) ?		insulitis